Results 161 to 170 of about 1,982 (196)

The Total Synthesis of Lasalocid A

1980
A total asymmetric synthesis of the "right half ketone" of the stereo-complex polyether antibiotic, lasalocid A, is described. The [3,3] sigmatropic rearrangements of 0-silylketene acetals derived from esters of 1,4-anhydro-pent-1-enitols (furanoid glycals) and 1,5-anhydro-hex-1-enitols (pyranoid glycals) provided α-substituted-2,5-dihydrofuran-2 ...
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Control of coccidia in young calves using lasalocid

Australian Veterinary Journal, 1995
SUMMARY Thirty‐six, 2‐ to 4‐day‐old Friesian bull calves were divided into 4 groups and fed milk replacer and calf starter pellets ad libitum in separate pens. Four treatments were applied; lasalocid in milk (1 mg/kg body weight/day) (M), lasalocid in starter (F), lasalocid in both milk and starter (M+F) and untreated (C).
McMeniman, N. P., Elliott, R.
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Effects of adaptation to lasalocid, monensin or a daily rotation of lasalocid and monensin on in vitro fermentation of a 90% concentrate diet

Canadian Journal of Animal Science, 1995
Effects of adaptation to L, M or a daily rotation of L and M (R) on in vitro fermentation were measured in a replicated in vitro experiment with a 4 × 4 factorial arrangement of treatments. Treatments were adaptation of ruminal fluid donor steers (0 or 200 mg steer−1 d−1 of L, M or R) and culture ionophore treatment (0 or 4 μg mL−1 of L, M or a 50:50 ...
G. C. Duff, M. L. Galyean, M. E. Branine
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The solution structure of a lasalocid A metal complex in lipophilic solvents

Bioorganic & Medicinal Chemistry, 2005
Lasalocid A (LasNa), a common antibiotic in veterinary medicine, is a polyetheral ionophore, disrupting cation equilibria through the cell wall. By means of circular dichroism (in the UV and in the near-IR), paramagnetic NMR, and with the aid of the program PERSEUS, we determined the solution geometry of the 1:1 Las-Yb3+ complex in CD3CN and CDCl3 ...
Ripoli, Silvia, SCARANO, SIMONA, Di Bari, Lorenzo, Salvadori, Piero   +3 more
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Thermodynamic analysis of amines-lasalocid complex formation

Biophysical Chemistry, 1997
The ionophore lasalocid A selectively transports amines across lipid membranes. Free energy differences of amine-lasalocid complex formation reactions and the activation barriers of the complex transport were calculated by the finite difference thermodynamic integration method.
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Prevention of Lactic Acidosis in Cattle by Lasalocid or Monensin

Journal of Animal Science, 1981
Intraruminal administration of lasalocid or monensin (1.3 mg/kg body weight) effectively prevented in glucose- or corn-induced lactic acidosis in cattle. Administering the antibiotics for 7 days before experimentally inducing acidosis with corn (27.5 g/kg body weight), effectively prevented acidosis, while 2 days' were sufficient to prevent glucose ...
T G, Nagaraja, T B, Avery, E E, Bartley, S J, Galitzer, A D, Dayton   +4 more
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A total synthesis of lasalocid A

Journal of the American Chemical Society, 1978
T. Nakata, G. Schmid, B. Vranesic, M. Okigawa, T. Smith-Palmer, Y. Kishi   +5 more
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Suspected lasalocid poisoning in three dogs.

Veterinary and human toxicology, 2003
The ionophore lasalocid has been used as a feed additive for broilers chickens and for improving feed efficiency in ruminants. Although dogs appear to be more sensitive to lasalocid intoxication than other species, there is only 1 report in the veterinary literature about lasalocid poisoning in dogs.
L, Espino, M L, Suarez, N, Miño, A, Goicoa, L E, Fidalgo, G, Santamarina   +5 more
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Efficacy of Lasalocid against Coccidia in Cattle

The Journal of Parasitology, 1979
P R, Fitzgerald, M E, Mansfield
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Neurotoxic action of lasalocid at high doses

Veterinary Record, 1985
A, Shlosberg, Y, Weisman, U, Klopfer, S, Perl   +3 more
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