Results 201 to 210 of about 208,806 (265)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Evaluation of the Efficacy of Plasma Shower and 585 Nm Q-Switched Laser in the Treatment of Mild to Moderate Acne Vulgaris. [PDF]

J Cosmet Dermatol
Bakircioglu CA, Turkmen D, Altunisik N, Kanat Z, Sener S, Colak C.   +5 more
europepmc   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Turbulence-Resistant Femtosecond Filaments via Nonlinear Self-Guiding and OAM Modulation. [PDF]

Sensors (Basel)
Liu J, Yang X, Jin W, Ren Z, Yang C, Shi T.   +5 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Single-event fast neutron time-of-flight spectrometry with a petawatt-laser-driven neutron source. [PDF]

Nat Commun
Millán-Callado MA, Scheuren S, Alejo A, Benlliure J, Beyer R, Cowan TE, Fernández B, Griesmayer E, Junghans AR, Kohl J, Kroll F, Metzkes-Ng J, Prencipe I, Quesada JM, Rehwald M, Rödel C, Rodríguez-González T, Schramm U, Roth M, Štefaníková R, Urlass S, Weiss C, Zeil K, Ziegler T, Guerrero C.   +24 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Interaction analysis of tight junction proteins by Förster resonance energy transfer is recommended in live cells rather than after paraformaldehyde fixation. [PDF]

Front Physiol
Przibylla-Diop C, Musinszki M, Bleich M, Milatz S.   +3 more
europepmc   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Multi-messenger dynamic imaging of laser-driven shocks in water using a plasma wakefield accelerator. [PDF]

Nat Commun
Balcazar MD, Tsai HE, Ostermayr TM, Campbell P, Trantham MR, Albert F, Chen Q, Colgan C, Dyer GM, Eisentraut Z, Esarey E, Grace ES, Greenwood B, Gonsalves AJ, Hakimi S, Jacob R, Kettle B, King P, Krushelnick K, Lemos N, Los EE, Ma Y, Mangles SPD, Nees J, Pagano IM, Schroeder CB, Simpson RA, Vazquez AV, van Tilborg J, Geddes CGR, Thomas AGR, Kuranz CC.   +31 more
europepmc   +1 more source