Results 51 to 60 of about 198,247 (300)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Longtitudinal electron beam diagnostics via upconversion of THz to visible radiation [PDF]

, 2009
Longitudinal electro-optic electron bunch diagnostics has been successfully applied at several accelerators. The electro-optic effect can be seen as an upconversion of the Coulomb field of the relativistic electron bunch (THz radiation) to the visible ...
Berden, G., Gillespie, W. A., Jamison, S. P., MacLeod, Allan M., Phillips, P. J., van der Meer, A. F. G.   +5 more
core  

LISA and LISA PathFinder, the endeavour to detect low frequency GWs

, 2006
This is a review about LISA and its technology demonstrator, LISA PathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then ...
, , A Conchillo, A Lobo, Araújo H M, Astone P, Bender P L, Boatella C, C Boatella, C Grimani, C Puigdengoles, Drever R W P, E García-Berro, Einstein A, Folkner W M, Fritschel P, H Araújo, Hammesfahr A, Heinzel G, Hewitson M, J A Ortega, J Ramos-Castro, J Sanjuán, Landau L D, Ll Martínez, Lobo J A, Lobo J A, Lobo J A, M Chmeissani, M Nofrarias, Martínez L, Nofrarias M, Nofrarias M, P Wass, Pais A, Ramos-Castro J, Sigg D, Tinto M, Vitale S, Vitale S, W Hajdas, Wass P, Weinberg S, Weisberg J M, X Xirgu   +44 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Review on Homogeneous Charge Compression Ignition and Low Temperature Combustion by Optical Diagnostics

Journal of Chemistry, 2015
Optical diagnostics is an effective method to understand the physical and chemical reaction processes in homogeneous charge compression ignition (HCCI) and low temperature combustion (LTC) modes.
Chao Jin, Zunqing Zheng
doaj   +1 more source

Spontaneous Raman scattering for simultaneous measurements of in-cylinder species [PDF]

, 2007
A technique for multi-species mole fraction measurement in internal combustion engines is described. The technique is based on the spontaneous Raman scattering. It can simultaneously provide the mole fractions of several species of N-2, O-2, H2O, CO2 and
Grunefeld G, Grunefeld G, H Zhao, Hinze P C, Johnston S C, Johnston S C, Knapp M, Mattias Richter, Miles P, Miles P C, S Zhang, Schutte M, Zhao H   +12 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Assessing optical damage risks by simulating the amplification of back-reflection in a multi-petawatt laser system

High Power Laser Science and Engineering
A technique developed to accurately simulate the amplification of back-reflected light through a multi-petawatt laser system is presented. Using the Frantz–Nodvik equation, we developed an iterative algorithm to simulate the amplification of the main ...
Dmitrii Nistor, Alice Diana Dumitru, Christophe Derycke, Olivier Chalus, Daniel Ursescu, Catalin Ticos   +5 more
doaj   +1 more source

Simultaneous high-resolution x-ray backlighting and self-emission imaging for laser-produced plasma diagnostics using a two-energy multilayer Kirkpatrick–Baez microscope

Matter and Radiation at Extremes, 2022
A simultaneous high-resolution x-ray backlighting and self-emission imaging method for laser-produced plasma diagnostics is developed in which two Kirkpatrick–Baez imaging channels for high-energy and low-energy diagnostics are constructed using a ...
S. Z. Yi, J. Q. Dong, L. Jiang, Q. S. Huang, E. F. Guo, Wang Z. S.   +5 more
doaj   +1 more source