Results 51 to 60 of about 45,819 (239)
CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis
Advanced Science, EarlyView.Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou +5 more
wiley +1 more source
Problem of nuclear-laser power engineering and methods of their solution [PDF]
Nuclear Energy and Technology, 2019 The concept of a high power reactor-laser system based on a nuclear pumped optical quantum amplifier (OKUYaN) was formulated at IPPE in the mid-1980-ies.
Petr P. Dyachenko +3 more
doaj +3 more sources
Fast ignition of fusion targets by laser-driven electrons
, 2008 We present hybrid PIC simulations of fast electron transport and energy deposition in pre-compressed fusion targets, taking full account of collective magnetic effects and the hydrodynamic response of the background plasma.
Bell A R +6 more
core +1 more source
Spontaneous Raman scattering for simultaneous measurements of in-cylinder species [PDF]
, 2007 A technique for multi-species mole fraction measurement in internal combustion engines is described. The technique is based on the spontaneous Raman scattering. It can simultaneously provide the mole fractions of several species of N-2, O-2, H2O, CO2 and
Grunefeld G +12 more
core +1 more source
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
The NIF: An international high energy density science and inertial fusion user facility
EPJ Web of Conferences, 2013 The National Ignition Facility (NIF), a 1.8-MJ/500-TW Nd:Glass laser facility designed to study inertial confinement fusion (ICF) and high-energy-density science (HEDS), is operational at Lawrence Livermore National Laboratory (LLNL).
Moses E.I., Storm E.
doaj +1 more source
Fire ignition during laser surgery in pet rodents
BMC Veterinary Research, 2012 Background Laser surgery is an attractive alternative to other means of section device in terms of tissue inflammation and interaction, which has been extensively used in human and veterinary medicine.
Collarile Tommaso +4 more
doaj +1 more source
Laser ignition of pulverized coals
Combustion and Flame, 1994 Abstract We present a novel experiment to study the ignition of pulverized coal. A dilute stream of particles is dropped into a laminar, upward-flow wind tunnel with a quartz test section. The gas stream is not preheated. A single pulse from a Nd:YAG laser is focused through the tunnel and ignites the fuel. The transparent test section and cool walls
Chen, John C. +3 more
openaire +3 more sources
Advanced Science, EarlyView.Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
, 2012 Transport modeling of idealized, cone-guided fast ignition targets indicates the severe challenge posed by fast-electron source divergence. The hybrid particle-in-cell [PIC] code Zuma is run in tandem with the radiation-hydrodynamics code Hydra to model ...
A. J. Kemp +14 more
core +1 more source