Results 51 to 60 of about 1,229,375 (235)

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Fire ignition during laser surgery in pet rodents

BMC Veterinary Research, 2012
Background Laser surgery is an attractive alternative to other means of section device in terms of tissue inflammation and interaction, which has been extensively used in human and veterinary medicine.
Collarile Tommaso, Di Girolamo Nicola, Nardini Giordano, Ciraci Ivano, Selleri Paolo   +4 more
doaj   +1 more source

Problem of nuclear-laser power engineering and methods of their solution [PDF]

Nuclear Energy and Technology, 2019
The concept of a high power reactor-laser system based on a nuclear pumped optical quantum amplifier (OKUYaN) was formulated at IPPE in the mid-1980-ies.
Petr P. Dyachenko, Anatoly V. Zrodnikov, Oleg F. Kukharchuk, Alexey A. Suvorov   +3 more
doaj   +3 more sources

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Deciphering Polarity Effects of Polymer to Regulate Li+ Ionic Environment in Solid Polymer Electrolytes for Solid‐State Lithium Batteries

Carbon Energy, EarlyView.
We elucidate the fundamental influences of polymer polarity on Li+ ionic environments in solid polymer electrolytes by considering four critical components: Li+, FSI−, residual solvents, and polymer matrix. Beyond facilitating LiFSI dissociation and Li+ transport, our findings underscore previously overlooked roles of polymer polarity, thereby ...
Ji‐Oh Kim, Taekyun Kwon, Hyeonchul So, Seungjo Hong, Hansol Lee, Jusung Han, Sung Hyun Kwon, Jin Hong Lee   +7 more
wiley   +1 more source

Effect of al content on reaction laser sintering of Ni-Al powder [PDF]

Science of Sintering, 2008
Laser reactive sintering, i.e., laser-induced self-propagating reaction sintering synthesis was used for the preparation of nickel aluminide intermetallic compounds.
Qin L., Hu J., Cui C., Wang H., Guo Z.
doaj   +1 more source

AI‐Enhanced Laser Manufacturing: A Social Life Cycle Perspective From the White Goods Industry

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Sustainable manufacturing transitions require companies to demonstrate not only environmental and economic benefits, but also measurable advances in corporate social responsibility (CSR). Therefore, we propose using a guideline‐based Social Life Cycle Assessment (S‐LCA) aligned with UNEP (2020) and ISO 14075 (2024) to evaluate the social ...
Ricardo Mejía‐Marchena, José Osorio‐Tejada, Farshid Sadeghi‐Khanegah, Abdullah Sert, Volker Hessel   +4 more
wiley   +1 more source

Laser-direct-drive program: Promise, challenge, and path forward

Matter and Radiation at Extremes, 2017
Along with laser-indirect (X-ray)-drive and magnetic-drive target concepts, laser direct drive is a viable approach to achieving ignition and gain with inertial confinement fusion.
E.M. Campbell, V.N. Goncharov, T.C. Sangster, S.P. Regan, P.B. Radha, R. Betti, J.F. Myatt, D.H. Froula, M.J. Rosenberg, I.V. Igumenshchev, W. Seka, A.A. Solodov, A.V. Maximov, J.A. Marozas, T.J.B. Collins, D. Turnbull, F.J. Marshall, A. Shvydky, J.P. Knauer, R.L. McCrory, A.B. Sefkow, M. Hohenberger, P.A. Michel, T. Chapman, L. Masse, C. Goyon, S. Ross, J.W. Bates, M. Karasik, J. Oh, J. Weaver, A.J. Schmitt, K. Obenschain, S.P. Obenschain, S. Reyes, B. Van Wonterghem   +35 more
doaj   +1 more source

Ultrafast Transitions in X‐Ray Irradiated Solids

Contributions to Plasma Physics, EarlyView.
ABSTRACT In this review, we present current developments on modeling ultrafast transitions in solids triggered by intense, atto‐ to femtosecond pulses from X‐ray free electron lasers. This specific irradiation regime requires dedicated simulation tools based on theoretical and computational methods, involving the elements of classical and quantum ...
Sebastião Antunes, Konrad J. Kapcia, Vladimir Lipp, Beata Ziaja   +3 more
wiley   +1 more source