Results 101 to 110 of about 21,821,173 (350)

Femtosecond laser processing of microcavity lasers

Frontiers of Optoelectronics, 2016
In this paper, we reviewed the fabrications of functional microcavity lasers in soft materials such as polymer and protein by femtosecond laser processing. High-quality (Q) microdisks with a laser dye (Rhodamine B, RhB) acting as gain medium were fabricated that produced whispering-gallery-mode (WGM) lasing output.
Xuepeng Zhan, Huailiang Xu, Hongbo Sun
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental Demonstration of Time-Delay Interferometry for the Laser Interferometer Space Antenna

, 2010
We report on the first demonstration of time-delay interferometry (TDI) for LISA, the Laser Interferometer Space Antenna. TDI was implemented in a laboratory experiment designed to mimic the noise couplings that will occur in LISA.
Brent Ware, D. A. Shaddock, D. A. Shaddock, Daniel A. Shaddock, Glenn de Vine, Kirk McKenzie, Robert E. Spero, W. Klipstein, William M. Klipstein   +8 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Three-dimensional femtosecond laser processing for lab-on-a-chip applications

, 2018
The extremely high peak intensity associated with ultrashort pulse width of femtosecond laser allows us to induce nonlinear interaction such as multiphoton absorption and tunneling ionization with materials that are transparent to the laser wavelength ...
F. Sima, K. Sugioka, R. Vázquez, R. Osellame, L. Kelemen, P. Ormos   +5 more
semanticscholar   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Laser processing quality monitoring by combining acoustic emission and machine learning: a high-speed X-ray imaging approach

, 2018
In situ and real-time monitoring of laser processes are very challenging due to complex dynamics of the laser-matter interactions. Acoustic emission (AE) technique is often used as non-destructive monitoring of many kinds of processes.
existing K. Wasmer K. Wasmer, products T. Le-Quang T. Le-Quang, A. Meylan, oriented F. Vakili-Farahani F. Vakili-Farahani, product family M.P. Olbinado M.P. Olbinado, P. B., European Synchrotron Jean-Yves Dantan European Synchrotron, F-38043 Grenoble F-38043 Grenoble Alain Etienne, Ali Siadat France France, A. Rack, S. Shevchik   +10 more
semanticscholar   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Biomimetic surface structures in steel fabricated with femtosecond laser pulses: influence of laser rescanning on morphology and wettability

Beilstein Journal of Nanotechnology, 2018
The replication of complex structures found in nature represents an enormous challenge even for advanced fabrication techniques, such as laser processing.
Camilo Florian Baron, Alexandros Mimidis, Daniel Puerto, Evangelos Skoulas, Emmanuel Stratakis, Javier Solis, Jan Siegel   +6 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source