Results 71 to 80 of about 361,513 (267)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Interest point detection from multi‐beam light detection and ranging point cloud using unsupervised convolutional neural network

IET Image Processing, 2021
Interest point detection plays an important role in many computer vision applications. This work is motivated by the light detection and ranging odometry task in autonomous driving.
Deyu Yin, Qian Zhang, Jingbin Liu, Xinlian Liang, Yunsheng Wang, Shoubin Chen, Jyri Maanpää, Juha Hyyppä, Ruizhi Chen   +8 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Multisource Single-Tree Inventory in the Prediction of Tree Quality Variables and Logging Recoveries

Remote Sensing, 2014
The stem diameter distribution, stem form and quality information must be measured as accurately as possible to optimize cutting. For a detailed measurement of the stands, we developed and demonstrated the use of a multisource single-tree inventory (MS ...
Mikko Vastaranta, Ninni Saarinen, Ville Kankare, Markus Holopainen, Harri Kaartinen, Juha Hyyppä, Hannu Hyyppä   +6 more
doaj   +1 more source

Scanning laser polarimetry in glaucoma

Indian Journal of Ophthalmology, 2014
Glaucoma is an acquired progressive optic neuropathy which is characterized by changes in the optic nerve head and retinal nerve fiber layer (RNFL). White-on-white perimetry is the gold standard for the diagnosis of glaucoma. However, it can detect defects in the visual field only after the loss of as many as 40% of the ganglion cells.
Tanuj Dada, Reetika Sharma, Dewang Angmo, Gautam Sinha, Shibal Bhartiya, Sanjay K Mishra, Anita Panda, Ramanjit Sihota   +7 more
openaire   +3 more sources

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Quantitative Assessment of Scots Pine (Pinus Sylvestris L.) Whorl Structure in a Forest Environment Using Terrestrial Laser Scanning

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2018
State-of-the-art technology available at sawmills enables measurements of whorl numbers and the maximum branch diameter for individual logs, but such information is currently unavailable at the wood procurement planning phase.
Jiri Pyorala, Xinlian Liang, Mikko Vastaranta, Ninni Saarinen, Ville Kankare, Yunsheng Wang, Markus Holopainen, Juha Hyyppa   +7 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source