Results 71 to 80 of about 104,727 (309)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Comparative analysis of the DFB fiber laser and fiber-optic interferometric strain sensors

, 2007
The DFB fiber laser strain sensor is shown to provide an improvement in the minimum detectable length change by a factor of 275 at 2 kHz for an applied strain when compared with an interferometric sensor interrogated by at equivalent DFB laser.
C. K. Kirkendall, G. M. H. Flockhart, Kirkendall, C. K., Cranch, G. A., G. A. Cranch, Flockhart, G. M. H.   +5 more
core   +1 more source

Biosensors for Brain Trauma and Dual Laser Doppler Flowmetry: Enoxaparin Simultaneously Reduces Stroke-Induced Dopamine and Blood Flow while Enhancing Serotonin and Blood Flow in Motor Neurons of Brain, In Vivo

Sensors, 2010
Neuromolecular Imaging (NMI) based on adsorptive electrochemistry, combined with Dual Laser Doppler Flowmetry (LDF) is presented herein to investigate the brain neurochemistry affected by enoxaparin (Lovenox®), an antiplatelet/antithrombotic medication ...
Edwin H. Kolodny, Patricia A. Broderick
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fibre segment interferometry using code-division multiplexed optical signal processing for strain sensing applications [PDF]

, 2013
A novel optical signal processing scheme for multiplexing fibre segment interferometers is proposed. The continuous-wave, homodyne technique combines code-division multiplexing with single-sideband modulation.
Charrett, Thomas O. H., Tatam, Ralph P., Kissinger, Thomas   +2 more
core   +1 more source

Optical Feedback Interferometry Flowmetry Sensor in Microfluidics Chip

Proceedings, 2017
Optical feedback interferometry (OFI) applied to microscale flow sensing is studied theoretically and experimentally. A new model is investigated that predicts the OFI signal.
Yu Zhao, Julien Perchoux, Thierry Camps, Véronique Bardinal   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Multi-component strain development in superconducting magnet coils monitored using fibre Bragg grating sensors fabricated in highly linearly birefringent fibre [PDF]

, 2011
The commissioning of superconducting magnet coils was monitored using embedded optical fibre Bragg grating sensors (FBG) fabricated in highly linearly birefringent (HiBi) fibre.
Adam Johnstone, Stephen J Buggy, James, Stephen W., M’hamed Lakrimi, Andrew Twin, Twin, Andrew, Ralph P Tatam, Domptail, Fred, Lakrimi, M’hamed, Tatam, Ralph P., Stephen W James, Chehura, Edmon, Johnstone, Adam, Buggy, Stephen J., Edmon Chehura, Fred Domptail   +15 more
core   +1 more source

Sustainable Corrosion Protection of Aluminium Alloys – Life Cycle Assessment of Established and Innovative Coating Processes

Tehnički Glasnik
Aluminium alloys are highly valued for their lightweight properties. However, their susceptibility to corrosion, particularly in chloride-containing environments, presents significant challenges especially when considering "green" sustainable processing ...
Juergen M. Lackner, Reinhard Kaindl, Sara Carniello, Simon Chwatal, Max Stummer   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source