Results 161 to 170 of about 4,592,774 (277)

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Detection of non-invasive sexing of early chick embryos in intact eggs using laser speckle contrast imaging and deep neural networks. [PDF]

PLoS One
Mahler S, Arora A, Readhead C, Yin S, Hari SN, Wang E, Moxley CI, Adeboye AA, Dong Z, Zhou H, Chen X, Bronner M, Yang C.   +12 more
europepmc   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Green channel-informed collaborative filtering for high-fidelity laser speckle contrast imaging in dual-display laparoscopy. [PDF]

Biomed Opt Express
Xue Y, Liu J, Zhou W, Xu B, Sun J, Yang X.   +5 more
europepmc   +1 more source

Laser-Speckle Contrast Imaging [PDF]

JAMA Dermatology, 2014
Anna E, Stanhewicz, Sara B, Ferguson, Rebecca S, Bruning, Lacy M, Alexander   +3 more
openaire   +2 more sources

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Intraoperative Laser Speckle Contrast Imaging To Assess Vessel Flow In Neurosurgery

Brain and Spine, 2023
Johannes Goldberg, David Miller, Alexis Dimanche, Cedric Kissling, Timothy Müller, Mandy Müller, Michael Murek, David Bervini, Andrew Dunn, Andreas Raabe   +9 more
doaj   +1 more source

Intraoperative tracking of tissue perfusion during cerebral aneurysm surgery with laser speckle contrast imaging: insights beyond standard intraoperative neuromonitoring for detecting ischemia. [PDF]

Neurophotonics
Mercyshalinie ERS, Kharbat AF, Machiorlatti M, Dunn AK, Bauer A, Graffeo CS, Miller DR.   +6 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Burning Sensation and Facial Blood Flow in Rosacea Patients: An Exploration of an Invisible Symptom That Cannot Be Overlooked

Clinical, Cosmetic and Investigational Dermatology
Yuwei Huang,1,2,* Xu Liu,1,2,* Yingying Dai,1,2 Xian Jiang1,2 1Department of Dermatology, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and ...
Huang Y, Liu X, Dai Y, Jiang X
doaj