Results 51 to 60 of about 3,121,676 (257)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

VRP-street-network

, 2022
What's Changed Create CODE_OF_CONDUCT.md by @Gui-FernandesBR in https://github.com/Gui-FernandesBR/Last-Mile-Routing-Analyzer/pull/1 Workflows by @Gui-FernandesBR in https://github.com/Gui-FernandesBR/Last-Mile-Routing-Analyzer/pull/2 Enh/lmr package ...
Alves, Guilherme F
core   +1 more source

Solution‐Processed Multi‐Junction Optoelectronic Synapses for Mode‐Switchable SWIR Neuromorphic Vision Sensing

Advanced Science, EarlyView.
A novel bias‐programmable shortwave infrared (SWIR) vision sensor is developed using multi‐junction colloidal quantum dots (QDs). Under varying applied voltage, the back‐to‐back rectifying junctions effectively tune trapping centers to switch the device between high‐speed photodetector and persistent synapse modes.
Zhuoyang He, Dae Yang Oh, Yi Ji, Yanyan Li, Chengwei Shan, Soong Ju Oh, Tianshuo Zhao   +6 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Essential aid made fully visible: understanding the proCHW financing landscape analysing accessible donor data sources

BMJ Global Health
Introduction Community health workers (CHWs) play a critical role in extending healthcare services to underserved populations, especially in low-income and middle-income countries.
James O’Donovan, Daniel Palazuelos, Madeleine Ballard, Mallika Raghavan, Stephanie Rapp, Ash Rogers, Carla López Castañeda, Benedicte Razafinjato, Matthew French, Cleo Baskin, Sarah Lindsay, Carey Carpenter Westgate, Laura Shellaby, Rachel Hofmann, Pauline Picho Keronyai, Niloofar Ganjian, Sonia Tiedt, Diana Nambatya Nsubuga, Jude Aidam   +18 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

In Situ Generation of Gel Foam via Heat‐Accelerated Calcium Ion Release From Nano‐CaCO3 for Lithium‐Ion Battery Fire Suppression and Prevention

Advanced Science, EarlyView.
We present a heat‐accelerated in situ crosslinking strategy to create an alginate gel foam for lithium‐ion battery fire suppression. At ambient temperature, the formulation maintains low viscosity for easy foam generation. After exposure to fire, δ‐gluconolactone hydrolysis accelerates, enabling rapid Ca2+ release from CaCO3 and rapid ionic ...
Xiaoyang Yu, Cuiping Li, Mingjun Xu, Man Pun Wan   +3 more
wiley   +1 more source

Robotics in Last Mile Delivery [PDF]

, 2021
Drones, bots, and autonomous vehicles, oh my! The innovation hype surrounding these autonomous delivery devices has the logistics industry striving to implement automated last mile delivery strategies.
Thomassy, Virginia L
core  

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Changing power narratives: an exemplar case study on the professionalisation of community health workers in Liberia

BMJ Global Health
Despite their central role in achieving health equity and Universal Health Coverage, only a minority of community health workers (CHWs) is formally recognised as health workforce and receives a salary.
Helene-Mari van der Westhuizen, Marion Subah, Anne Neumann   +2 more
doaj   +1 more source