Results 71 to 80 of about 4,421,050 (337)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

On the last mile: logistical urbanism and the transformation of labour

Work Organisation, Labour and Globalisation, 2019
In recent years, the last mile of delivery has become a crucial focus of logistical operations in urban contexts due to the rise of online shopping and the spread of platforms including Amazon to Foodora, Deliveroo and others ...
Moritz Altenried
doaj   +1 more source

Park and parcel: an agent-based exploration of last-mile freight delivery behavior as it relates to parking [PDF]

, 2019
Light goods vehicles are an important part of London traffic. With changes to delivery demand and traffic patterns more broadly, they often have a disproportionate impact on the functioning of cities.
Tolga Bektas, Tom Cherrett, Bektas, T., Fraser McLeod, McLeod, F, Allen, Julian, Bektas, Tolga, Cheliotis, K., Cherrett, Tom, Piecyk, Maja, Julian Allen, Cheliotis, K, Bektas, T, Bates, O, Maja Piecyk, Bates, O., Kostas Cheliotis, Oliver Bates, Wise, S., Piecyk, M., Wise, Sarah, McLeod, Fraser, Piecyk, M, Cherrett, T., Cheliotis, Kostas, Bates, Oliver, Wise, S, Cherrett, T, Allen, J, McLeod, F., Sarah Wise, Allen, J.   +31 more
core   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Taxonomy of key practices for a sustainable Last-Mile logistics network in E-Retail: A comprehensive literature review

Cleaner Logistics and Supply Chain
Objective: The growth of e-commerce has transformed last-mile logistics, with direct-to-consumer deliveries and frequent delivery failures. This has exacerbated pollution and congestion issues, negatively impacting urban life.
María Alejandra Maldonado Bonilla, Marina Bouzon, Claudia Cecilia Peña-Montoya   +2 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

FACTORS AFFECTING THE SATISFACTION OF CUSTOMERS BUYING FOOD WITH LAST-MILE DELIVERY SERVICE ON E-COMMERCE PLATFORM IN VIETNAM [FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUASAN PELANGGAN YANG MEMBELI MAKANAN DENGAN LAYANAN PENGIRIMAN LAST-MILE PADA PLATFORM E-COMMERCE DI VIETNAM]

DeReMa (Development Research of Management): Jurnal Manajemen, 2023
The study aims to explore specific factors that affecting the satisfaction of customers buying food with last- mile delivery service on e-commerce platform in Vietnam.
Nhung Thi Hong Le, Phuong Mai Le, Huyen Thi Nguyen   +2 more
doaj   +1 more source

Framework for Truck-RPAS Hybrid Models in Last-Mile Delivery

Drone Systems and Applications
This study develops a hybrid optimization framework integrating Remotely Piloted Aircraft Systems (RPASs) with conventional truck delivery networks to enhance last-mile logistics efficiency.
A. Mahmoodi, Leila Hashemi, Jeremy Laliberte   +2 more
semanticscholar   +1 more source

Holistic Top‐to‐Bottom Film Restructuring to Achieve Highly Stable Unencapsulated Perovskite Solar Cells

Advanced Energy Materials, EarlyView.
A novel top‐to‐bottom film restructuring strategy is applied to perovskite films, taking advantage of high penetration of vapor‐phase ligand. A gradient‐distributed 2D perovskite structure is built up from top surface to film bulk, meanwhile, inhomogeneity at the buried interface is mitigated, which leads to high quality perovskite films with improved ...
Zhengyan Jiang, Jiayun Sun, Zhixian Zhang, Peide Zhu, Wenjun Liu, Biao Zhou, Hong Zhang, Baomin Xu, Wallace C. H. Choy   +8 more
wiley   +1 more source