Results 31 to 40 of about 19,763 (266)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Nineteenth and Twentieth Century Changes in Sea Level [PDF]
Oceanography, 2011 Following the Last Glacial Maximum (25,000–20,000 years ago), sea level rose at rates on the order of several tens of millimeters per year at times, and increased overall by over 130 m.
Philip L. Woodworth +2 more
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
VALE BOI (ALGARVE, PORTUGAL) AND THE SOLUTREAN IN SOUTHWESTERN IBERIA
Espacio, Tiempo y Forma. Serie I, Prehistoria y Arqueología, 2013 Located at the crossroads of two rather different ecological and cultural worlds (Mediterranean Spain and Portuguese Atlantic), the site of Vale Boi is a crucial element in understanding the economic and social traits of the communities that inhabited ...
João Cascalheira +10 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Contrasting the Penultimate Glacial Maximum and the Last Glacial Maximum (140 and 21 ka) using coupled climate–ice sheet modelling [PDF]
Climate of the PastThe configuration of the Northern Hemisphere ice sheets during the Penultimate Glacial Maximum differed to the Last Glacial Maximum. However, the reasons for this are not yet fully understood.
V. L. Patterson +8 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
North Atlantic Deep Water Production during the Last Glacial Maximum
Nature Communications, 2016 The nature of the overturning circulation in the Atlantic Ocean during the Last Glacial Maximum remains a topic of contention. Here, using neodymium isotope measurements, the authors demonstrate that North Atlantic Deep Water was produced under glacial ...
Jacob N. W. Howe +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source