Results 31 to 40 of about 2,146 (214)

Closing the sea level budget at the Last Glacial Maximum [PDF]

Proceedings of the National Academy of Sciences, 2014
Establishing the volume of excess ice contained in the global ice sheets during the Last Glacial Maximum (LGM; ∼26,000–19,000 y ago) remains a longstanding problem in Ice Age climate dynamics. Expressed as the equivalent lowering of global mean sea level (GMSL), estimates of this value have varied from 105 (1) to 163 m (2), with many estimates ...
Peter U, Clark, Lev, Tarasov
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Characteristics of Clay Minerals in Sediments of Xinghua Bay and Nanri Channel in Fujian Province and Their Paleoenvironmental Significance

Journal of Marine Science and Engineering
Under the background of global climate change, the evolution of climate in the future is the focus of geoscience. The Nanri Channel is an important passage connecting the Xinghua Bay and the Taiwan Strait, in China, and the study of its provenance and ...
Xin Li, Jinrong Wang, Ke Yin, Qin Chen, Wei Liu, Yanna Huang, Yongchao Wang, Zhishan Wu, Jiansui Lin   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mountain glacier extents at the Last Glacial Maximum

Scientific Data
Mountain regions experienced repeated glacial expansions and retreats during the Quaternary, shaping landscapes, ecosystems, and regional climates. While numerous reconstructions exist for individual mountain glaciers, global geodatabases remain scarce ...
Augusto C. Lima, Helen E. Dulfer, Anna L. C. Hughes, Martin Margold, Iestyn Barr, Benjamin J. C. Laabs, Suzette G. A. Flantua   +6 more
doaj   +1 more source

Nineteenth and Twentieth Century Changes in Sea Level [PDF]

Oceanography, 2011
Following the Last Glacial Maximum (25,000–20,000 years ago), sea level rose at rates on the order of several tens of millimeters per year at times, and increased overall by over 130 m.
Philip L. Woodworth, W. Roland Gehrels, R. Steven Nerem   +2 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

VALE BOI (ALGARVE, PORTUGAL) AND THE SOLUTREAN IN SOUTHWESTERN IBERIA

Espacio, Tiempo y Forma. Serie I, Prehistoria y Arqueología, 2013
Located at the crossroads of two rather different ecological and cultural worlds (Mediterranean Spain and Portuguese Atlantic), the site of Vale Boi is a crucial element in understanding the economic and social traits of the communities that inhabited ...
João Cascalheira, Nuno Bicho, João Marreiros, Telmo Pereira, Marina Évora, Miguel Cortés, Juan Gibaja, Tiina Manne, Frederico Regala, Célia Gonçalves, Patricia Monteiro   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source