Results 61 to 70 of about 19,763 (266)

Deglaciation of the Colorado Rocky Mountains following the Last Glacial Maximum

Cuadernos de Investigación Geográfica, 2017
The availability of almost 180 cosmogenic-radionuclide (CRN) surface-exposure ages from moraine boulders and glacially polished bedrock surfaces makes possible an assessment of the timing and character of the local Last Glacial Maximum (LLGM) and ...
E.M. Leonard, B.J.B. Laabs, A.D. Schweinsberg, C.M. Russell, J.P. Briner, N.E. Young   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Greenland Ice Cores Reveal a South‐To‐North Difference in Holocene Thermal Maximum Timings

Geophysical Research Letters
Holocene temperature evolution remains poorly understood. Proxies in the early and mid‐Holocene suggest a Holocene Thermal Maximum (HTM) where temperatures exceed the pre‐industrial, whereas climate models generally simulate monotonic warming.
Kaden C. Martin, Christo Buizert, Ed Brook, Olivia L. Williams, Jon S. Edwards, Ben Riddell‐Young, T. J. Fudge, Farhana Mederbel, Ross Beaudette, Jeff Severinghaus, Ikumi Oyabu, Kenji Kawamura, Marie Kirk, Iben Koldtoft, J. P. Steffensen, Thomas Blunier   +15 more
doaj   +1 more source

Deglaciation of the Laurentide Ice Sheet from the Last Glacial Maximum

Cuadernos de Investigación Geográfica, 2017
The last deglaciation of the Laurentide Ice Sheet (LIS) was associated with major reorganisations in the ocean-climate system and its retreat also represents a valuable analogue for understanding the rates and mechanisms of ice sheet collapse. This paper
Ch.R. Stokes
doaj   +1 more source

Glacial geomorphology of the Strait of Magellan ice lobe, southernmost Patagonia, South America

Journal of Maps, 2020
We present a geomorphic map of the landforms created by the Patagonian Ice Sheet during the local Last Glacial Maximum and perhaps prior glaciations in southernmost Patagonia. Building on prior work, the new mapping focuses in unprecedented detail on the
Rodrigo L. Soteres, Carly Peltier, Michael R. Kaplan, Esteban A. Sagredo   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Glacial activity and paleoclimatic evolution records in the Cosmonaut Sea since the last glacial maximum

Frontiers in Marine Science
This research explored the origin and paleoenvironmental significance of sediments from the Cosmonaut Sea, Antarctica, focusing on the period since the Last Glacial Maximum (LGM, 26,000 cal a BP).
Dong Chen, Dong Chen, Qian Ge, Qian Ge, Ziyan Lei, Bingfu Zhou, Bingfu Zhou, Xibin Han, Xibin Han   +8 more
doaj   +1 more source