Results 111 to 120 of about 1,465,091 (287)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Last Issue of Volume One

, 1964
This April issue represents the last of volume one. The Board of Directors of the Iowa Academy of Science will be deciding the fate of the journal on April ...

core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Africa Bibliography: change of editor

, 1992
The current issue of the Africa Bibliography–listing works published in 1990–is the last to be edited by Dr Hector Blackhurst, of the John Rylands University Library of Manchester.
Murray Last
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Sweet Portable You fanzine, Issue 21, October 25, 1989

, 1989
The twenty first issue of Sweet Portable You, a fanzine that covered the punk and alternative subcultures in the Washington, D.C. area. Issues typically consisted of one or two double-sided sheets of legal-sized paper and were distributed at local ...
Foster, Patrick
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

What's new in trachoma control?

Community Eye Health Journal, 2004
Progress towards elimination of blinding trachoma Ten years after the Community Eye Health Journal first devoted an entire issue to trachoma (Vol. 7, Issue 14), and five years since its last trachoma-focused edition (Vol.
Jacob Kumaresan
doaj  

How many seals were there? The global shelf loss during the Last Glacial Maximum and its effect on the size and distribution of grey seal populations

, 2012
The tagging studies were funded by the Natural Environment Research Council, UK; the Atlantic seal research program, Department of Fisheries and Oceans, Canada and NSERCD Discovery grants, Canada.
Boehme Lars, Hammill Mike O., Thompson Dave, Fedak Mike, Mike Fedak, Hammill, Mike, Garry B Stenson, Stenson Garry B., Mike O Hammill, Dave Thompson, Bowen, Don, Thompson, David, Bowen Don, Stenson, Gary, Don Bowen, Boehme, Lars, Fedak, Mike, Lars Boehme   +17 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source