Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Electronic Publishing Programs in Science and Technology Part 2: Abstracting and Indexing Services
In the last issue, we looked at electronic journals being made available over the world wide web. In this issue we survey indexing and abstracting services available over the web.
Elizabeth W. Brown, Andrea L. Duda
doaj +1 more source
The evolution of evaluation – the accelerating march towards the measurement of public relations effectiveness [PDF]
The measurement and evaluation of public relations effectiveness has long been a major professional and research issue (White and Blamphin 1994; Synnott and McKie 1997). Recently Watson (2008) found that it still ranked third in an international study of
Watson, Tom
core
Quantum-Gravity Phenomenology: Status and Prospects [PDF]
Over the last few years part of the quantum-gravity community has adopted a more optimistic attitude toward the possibility of finding experimental contexts providing insight on non-classical properties of spacetime.
Ahluwalia D.V. +13 more
core +3 more sources
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Introduction: there is more to Keynesianism than public spending alone
The brief note introduces the articles collected in the present issue of the journal. It places the various contributions in perspective, critically summarizing the major economic developments since the publication of the last issue.
Carlo D'Ippoliti
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Finsler metrics and relativistic spacetimes
Recent links between Finsler Geometry and the geometry of spacetimes are briefly revisited, and prospective ideas and results are explained. Special attention is paid to geometric problems with a direct motivation in Relativity and other parts of Physics.
Javaloyes, Miguel A., Sánchez, Miguel
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

