Results 231 to 240 of about 1,465,091 (287)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Special Issue "Neuropharmacology of Plant Extracts and Their Active Compounds". [PDF]

Pharmaceuticals (Basel)
Alonso-Castro AJ.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The pitfalls of transcatheter tricuspid valve repair: what we have learned in our last decade of experience. [PDF]

Ann Cardiothorac Surg
Corona S, Ben-Ali W, von Bardeleben S.
europepmc   +1 more source

ACP-EC Conventions of Lome. Compilation of texts XXIII. 1 January 1998 - 31 December 1998 [PDF]

, 2000

core  

Correction. [PDF]

Can Fam Physician
europepmc   +1 more source

Editorial for Special Issue "Microbial Safety and Beneficial Microorganisms in Foods". [PDF]

Microorganisms
Varzakas T.
europepmc   +1 more source

<i>Global Spine Journal</i> Heads Back to Global Spine Congress. [PDF]

Global Spine J
Wang JC, Chapman JR, Wiechert K.
europepmc   +1 more source

Antimicrobial stewardship and the antibiotic market: why "Reserve" drugs require new economic models. [PDF]

Ther Adv Drug Saf
Castellana E, Tarozzo A, Viglianti R, Molon C, Chiappetta MR.   +4 more
europepmc   +1 more source