Results 41 to 50 of about 4,334,600 (253)

Receptogenesis in a Vascularized Robotic Embodiment

Advanced Science, EarlyView.
Functional augmentation of situated robots via ex novo hardware generation extends physical adaptability. Drawing inspiration from open circulatory systems for mass and function redistribution, this study presents a vascularized robotic composite exhibiting receptogenesis ‐ the on‐demand construction of sensors ‐ from internal fluid reserves based on ...
Kadri‐Ann Pankratov, Leonid Zinatullin, Hans Priks, Adele Metsniit, Urmas Johanson, Tarmo Tamm, Alvo Aabloo, Edoardo Sinibaldi, Indrek Must   +8 more
wiley   +1 more source

A Comparative Review of Air Drones (UAVs) and Delivery Bots (SUGVs) for Automated Last Mile Home Delivery

, 2023
Background: UAVs (Unmanned Aerial Vehicles) and SUGVs (Sidewalk Unmanned Ground Vehicles) are two prominent options to revolutionize last mile home delivery. However, there is no literature yet addressing a comprehensive assessment of them.
Oliver Kunze, Li, Fang, Fang Li, Kunze, Oliver   +3 more
core   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Optimizing Last-Mile Deliveries: Addressing Customer Absence Through Genetic Algorithm

Technologies
Last-mile delivery logistics face significant challenges, particularly regarding customer absences during scheduled delivery times. This issue not only frustrates customers but also imposes substantial economic costs on delivery companies, estimated at ...
Javier Sánchez-Soriano, Guillermo Verdín-Urgal, Natalia Gordo-Herrera   +2 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Analysis of logistics measures of CEP service providers for the last-mile delivery in small- and medium-sized cities: A case study for the Aachen city region

European Transport Research Review
The e-commerce sector’s rapid expansion has led to an increase in delivery activities both within and across cities, fuelling the growth of the courier, express, and parcel (CEP) services.
Abdulrahmon Ghazal, Santhanakrishnan Narayanan, Ibraheem Oluwatosin Adeniran, Carina Kehrt, Constantinos Antoniou   +4 more
doaj   +1 more source

On the last mile: logistical urbanism and the transformation of labour

Work Organisation, Labour and Globalisation, 2019
In recent years, the last mile of delivery has become a crucial focus of logistical operations in urban contexts due to the rise of online shopping and the spread of platforms including Amazon to Foodora, Deliveroo and others ...
Moritz Altenried
doaj   +1 more source

Park and parcel: an agent-based exploration of last-mile freight delivery behavior as it relates to parking [PDF]

, 2019
Light goods vehicles are an important part of London traffic. With changes to delivery demand and traffic patterns more broadly, they often have a disproportionate impact on the functioning of cities.
Tolga Bektas, Tom Cherrett, Bektas, T., Fraser McLeod, McLeod, F, Allen, Julian, Bektas, Tolga, Cheliotis, K., Cherrett, Tom, Piecyk, Maja, Julian Allen, Cheliotis, K, Bektas, T, Bates, O, Maja Piecyk, Bates, O., Kostas Cheliotis, Oliver Bates, Wise, S., Piecyk, M., Wise, Sarah, McLeod, Fraser, Piecyk, M, Cherrett, T., Cheliotis, Kostas, Bates, Oliver, Wise, S, Cherrett, T, Allen, J, McLeod, F., Sarah Wise, Allen, J.   +31 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source