Results 81 to 90 of about 22,682,546 (270)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The application of a pilot pull planning system to construction projects [PDF]

, 2002
A new planning system was introduced as a pilot within a large UK construction company. The system, which attempts to address some of the problems of construction “front end” planning, is investigated relative to Lean Construction and specifically the ...
Johansen, Eric
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Analisis Implemetasi LPS Pada Proyek Konstruksi dengan Menggunakan Aplikasi Primavera P6 Pada Tahap Pelaksanaan

Teras Jurnal: Jurnal Teknik Sipil
Keterlambatan pelaksanaan proyek konstruksi masih menjadi permasalahan utama yang berdampak pada penurunan produktivitas, dan ketidaktercapaian target waktu.
Noorma Putri Rajati, Kezia Micelle Permata Harsono, Hermawan Hermawan, Felix Hidayat   +3 more
doaj   +1 more source

THE PROSPECT OF MINIMISING PRODUCTION FLOW WASTE ON CONSTRUCTION SITES IN NIGERIA THROUGH THE LAST PLANNER® SYSTEM

Journal of Construction Project Management and Innovation, 2017
Poor performance of construction projects is a re-occurring problem in Nigeria. Production flow waste (ranging from waiting time, material handling and over- production, among others) may be partly responsible for this problem. Meanwhile, very little is
Emmanuel Itodo DANIEL, Christine PASQUIRE, Oko John AMEH   +2 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Integración de la metodología Lean en proyectos de construcción en México (2016–2022)

Revista Venezolana de Gerencia
La integración de la metodología de producción Lean en proyectos de construcción busca optimizar procesos, reducir desperdicios y mejorar la eficiencia, con el objetivo de entregar proyectos de mejor calidad a tiempo y dentro del presupuesto.
Andrés Bustos Acevedo, Jesús García Guiliany, Annherys Paz Marcano, Mariby Boscán   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Guidelines for resolving safety constraints using the Last Planner System in Zimbabwean construction projects

Acta Structilia
Construction projects in Zimbabwe continue to experience performance challenges arising from persistent safety constraints. This study examines how the Last Planner System (LPS), a key Lean Construction tool, can be applied to reduce these safety-related
Cynthia Moyo, Fidelis Emuze, John Smallwood   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source