Results 71 to 80 of about 593,180 (349)

Nitroxide‐Mediated Photo‐Polymerization: A Swiss Army Knife for Microfluidic Design

Advanced Materials Technologies, EarlyView.
This article illustrates the application of NMP2 to the rapid (less than 1 h) photostructuring and sealing of model structures intended for microfluidic applications. Remarkably, the careful design of resin composition allows completing these steps by simply spreading bare monomer (i.e., no added photoinitiator) on top of the bottom layer embedding ...
Carlo Gonzato, Sandip Wadhai, Jean‐Louis Clement, Florent Malloggi, Yohann Guillaneuf, Olivier Soppera   +5 more
wiley   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Soils and Cultural Layer of Voznesenskoye I Settlement

Археология евразийских степей
The article examines the processes of cultural layer formation and their relationship with lithological, soil-forming, and other exogenous phenomena, which together constitute a unified natural-anthropogenic complex of processes.
Aleksandr L. Aleksandrovsky
doaj   +1 more source

AI‐Directed 3D Printing of Hierarchical Polyurethane Foams

Advanced Science, EarlyView.
Digitally guided direct ink writing, combined with AI‐generated design, enables the fabrication of hierarchical polyurethane foams with tunable multiscale porosity. This approach produces architected foams featuring interconnected open‐cell networks and tailored mechanical properties, advancing the development of adaptive, high‐performance materials ...
Dhanush Patil, Jie Tian, Kun Jiang, Clarissa Westover, Sri Vaishnavi Thummalapalli, Arunachalam Ramanathan, Arpita Shome, Natalie Crutchfield, M. Taylor Sobczak, Sean Lee, Hongyue Sun, Elizabeth J. Brisbois, Hitesh Handa, Timothy E. Long, Xianqiao Wang, Kenan Song   +15 more
wiley   +1 more source

The problem of the Early Bronze Age in the territory of north-eastern Serbia a contribution to the study of the Early Bronze Age in the Central Balkans [PDF]

Starinar
Despite a relatively high degree of archaeological research and related publications, the territory of north-eastern Serbia represents a “vacuum” of sites during the Early Bronze Age.
Mladenović Ognjen, Bulatović Aleksandar   +1 more
doaj   +1 more source

Systematic Benchmarking of a Noise‐Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics

Advanced Science, EarlyView.
General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen, Ioannis Ziogas, Shirina Alsaedi, Mouza Alshehhi, Shahd Almheiri, Adil Rehman, Khulood Al Shehhi, Hani Saleh, Ahsan Khandoker, Charalampos Pitsalidis, Antoun Khawaja, Anna‐Maria Pappa   +11 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

Urnfield Bronze Connections: Rethinking Late Bronze Age Mobility

, 2022
IIn this paper after a thorough critical review of existing theories about mobility, we try to put together a new, original theoretical and methodological perspective that integrates the kaleidoscopic range of human movement in ancient and modern times and by what means archaeologists should be able to track it and interpret its motivations.
Renan Falcheti Peixoto, Francesco Iacono
openaire   +1 more source