Results 61 to 70 of about 1,797,826 (252)

Reconstruction of ice-sheet changes in the Antarctic Peninsula since the Last Glacial Maximum [PDF]

, 2014
This paper compiles and reviews marine and terrestrial data constraining the dimensions and configuration of the Antarctic Peninsula Ice Sheet (APIS) from the Last Glacial Maximum (LGM) through deglaciation to the present day.
Glasser, N.F., Davies, Bethan J., Emma P. Hocking (7190990), Larter, Robert D., Larter, R.D., Anderson, J.B., John B. Anderson (7190993), Livingstone, Stephen J., Simms, A.R., Roberts, S.J., Ó Cofaigh, Colm, Domack, E., Evans, J., Hillenbrand, Claus-Dieter, James A. Smith (1496818), Livingstone, Stephen, Michael J. Bentley (7190996), Livingstone, S.J., Dowdeswell, Julian, Anderson, John B., Hocking, Emma, Eugene Domack (6507515), Anderson, John, Canals, M., Canals, Miquel, Roberts, Stephen J., Johnson, J.S., O Cofaigh, C., Stephen J. Roberts (7191008), Hillenbrand, C.D., Larter, Robert, Simms, Alexander, Neil F. Glasser (7191002), Hodgson, Dominic A., Smith, J.A., Julian A. Dowdeswell (7190999), Bentley, Michael J., Colm O Cofaigh (7190984), Jeffrey Evans (1254507), Dowdeswell, Julian A., Hocking, Emma P., Simms, Alexander R., Hillenbrand, Claus Dieter, Hodgson, D.A., Smith, James A., Bentley, M.J., Domack, Eugene, Dowdeswell, J.A., Davies, Bethan, Alexander R. Simms (7191011), Stephen J. Livingstone (3691018), Joanne S. Johnson (7190987), Robert D. Larter (7191005), Johnson, Joanne S., Bentley, Michael, Hodgson, Dominic, Bethan J. Davies (2843855), Glasser, Neil, Miquel Canals (186525), Claus-Dieter Hillenbrand (4276453), Dominic A. Hodgson (2043412), Evans, Jeffrey, Glasser, Neil F., Hillenbrand, C-D., Canals, Miguel, Hocking, E.P., Davies, B.J.   +66 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Late Glacial and Holocene shore-level changes in the Aarhus Bugt area, Denmark

GEUS Bulletin, 2021
We propose a new relative shore-level curve for the Aarhus Bugt area, an embayment in eastern Jylland, Denmark, based on a compilation of published and new radiocarbon ages of organic material.
Ole Bennike, Katrine Juul Andresen, Peter Moe Astrup, Jesper Olsen, Marit-Solveig Seidenkrantz   +4 more
doaj   +1 more source

PLANT MACROFOSSIL RECORDS | Late Glacial Multidisciplinary Studies [PDF]

, 2013
Amplitudes and rates of climate changes and environmental responses were especially high during the Late Glacial (ca. 16 000–11 500 years BP). By applying several methods on the same material (if possible on the same core to avoid correlation problems ...
Birks, H.H., A. Walanus, Ammann, Brigitta, Walanus, A., B. Ammann, Wasylikowa, K., H.H. Birks, K. Wasylikowa   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Late Glacial deglaciation of the Zackenberg area, NE Greenland

Geomorphology, 2022
The Greenland Ice Sheet (GrIS) is a key component of the global climate system. However, our current understanding of the spatio-temporal oscillations and landscape transformation of the GrIS margins since the last glacial cycle is still incomplete.
Garcia-Oteyza, J., Oliva, M., Palacios, D., Fernández-Fernández, J.M., Schimmelpfennig, I., Andrés, N., Antoniades, D., Christiansen, H.H., Humlum, O., Leanni, L., Jomelli, V., Ruiz-Fernández, J., Keddadouche, Karim, Rinterknecht, V.R., Lane, T.P., Adamson, K., Aumaître, G., Bourles, D.L.   +17 more
openaire   +8 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Diverse phenotypes of Late Glacial–Early Holocene downy birch (Betula pubescens Erh.) and the morphology of early Preboreal tree stands in southern Schleswig-Holstein [PDF]

Eiszeitalter und Gegenwart
The flexibility in growth of Betula pubescens is taken as example for possible erroneous imaginations of Late Glacial–Early Holocene living conditions.
S. Krüger
doaj   +1 more source

Life hung by a thread: endurance of Antarctic fauna in glacial periods [PDF]

, 2008
Today, Antarctica exhibits some of the harshest environmental conditions for life on Earth. During the last glacial period, Antarctic terrestrial and marine life was challenged by even more extreme environmental conditions.
Thatje, S., Hillenbrand, C.-D., Claus-Dieter Hillenbrand, Larter, Robert, Andreas Mackensen, Sven Thatje, Rob Larter, Thatje, Sven, Mackensen, Andreas, Larter, R., Mackensen, A., Hillenbrand, Claus-Dieter, Hillenbrand, C.D.   +12 more
core   +1 more source