Results 81 to 90 of about 1,797,826 (252)
Les Nouvelles de l’Archéologie, 2015 This collective project of research, which started in 2009, is dedicated to hunter-gatherers societies in Paris Basin from the fourteenth millenium cal BC until the sixth millenium cal BC, i.e during the Late Glacial and the beginning of the Post Glacial.
Boris Valentin
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Carbonate cementation in the late glacial outwash and beach deposits in northern Estonia [PDF]
Estonian Journal of Earth Sciences, 2014 The sedimentary environments, morphology and formation of carbonate cement in the late glacial glaciofluvial outwash and beach deposits in northern Estonia are discussed.
Maris Rattas, Pille Lomp, Argo Jõeleht
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late glacial sand dune topography
, 2021 late glacial sand dune topographyKelley NGGDPP Grant 2019https://digitalmaine.com/mgs_geologic_field_photos/13010/thumbnail ...
Kelley, Joseph
core
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The origin and evolution of small dry valleys in the last-glacial area on the example of the Pomeranian Lake District (Poland) [PDF]
Estonian Journal of Earth Sciences, 2019 Short dry valleys forming a part of the relief characteristic of the temperate zone occur particularly frequently in areas related to the young-glacial zone.
Marek Majewski, Renata Paluszkiewicz
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Using sea-level and land motion data to develop an improved glacial isostatic adjustment model for the British Isles [PDF]
, 2011 The Glacial Isostatic Adjustment (GIA) of the British Isles is of interest due to the constraints that can be provided on key model parameters such as regional ice sheet history, viscoelastic earth structure and the global meltwater (eustatic) signal ...
Bradley, Sarah Louise +1 more
core
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Journal of Limnology, 2002 Selected pigments, diatoms and diatom-inferred phosphorus (Di-TP) concentrations of a late glacial sediment core section of the meromictic Längsee, Austria, were compared with tephra- and varve-dated pollen stratigraphic and geochemical results.
Jens MÜLLER +4 more
doaj +1 more source