Results 81 to 90 of about 1,748,641 (295)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Palynology, vegetation and climate of the Waikato lowlands, North Island, New Zealand, since c. 18,000 years ago [PDF]

, 1989
The vegetational and climatic history of the Waikato lowlands during the last c. 18,000 years is inferred from the palynology of sediment cores from Lakes Rotomanuka, Rotokauri, and Okoroire.
Lowe, David J., Newnham, Rewi M., Green, John D.   +2 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The glacial geomorphology of the tweed valley and surrounding area, eastern British Isles. [PDF]

, 2009
This project focuses on reconstructing the glacial dynamics of the Tweed Valley and surrounding area in the Scottish Borders and northeast Northumberland from the glacial geomorphological record.
Staines, Kate E.H.
core  

Impact of late glacial climate variations on stratification and trophic state of the meromictic lake Längsee (Austria): validation of a conceptual model by multi proxy studies

Journal of Limnology, 2002
Selected pigments, diatoms and diatom-inferred phosphorus (Di-TP) concentrations of a late glacial sediment core section of the meromictic Längsee, Austria, were compared with tephra- and varve-dated pollen stratigraphic and geochemical results.
Jens MÜLLER, Christian KAMENIK, Peter INDINGER, Roland PSENNER, Roland SCHMIDT   +4 more
doaj   +1 more source

The Late‐glacial reoccupation of the British Isles and the Creswellian

Journal of Quaternary Science, 2003
AbstractThis paper presents a review of AMS radiocarbon dating evidence for human occupation of Britain during the Late‐glacial Interstadial. The dates are all on humanly modified materials, including artefacts, and on human bone. The CalPal program is used to test whether the earliest evidence of human presence shows any correlation with more ...
Barton, R, Jacobi, R, Stapert, D, Street, M   +3 more
openaire   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Significance of Hippophae rhamnoides L. in evolution of the Eemian Interglacial' flora in Warsaw area

Acta Societatis Botanicorum Poloniae, 2014
Palynologic studies of sediments from Warsaw-Wawrzyszew and other sites in the Warsaw Basin enabled to analyze main occurrence phases of Hippophae rhamnoides during the widely understood Lake Pleistocene interglacial warming.
Krzysztof M. Krupiński
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source