Results 201 to 210 of about 20,544 (264)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Synchronizing climate-carbon cycle heartbeats in the Phanerozoic vegetated icehouses. [PDF]

Nat Commun
Fang Q, Wu H, Montañez IP, Shen SZ, Zeeden C, Wang X, Zhang S, De Vleeschouwer D.   +7 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Orbital and millennial-scale forcing of the Patagonian Ice Sheet throughout the Last Glacial Cycle. [PDF]

Nat Commun
Castillo-Llarena A, Prange M, Rogozhina I.   +2 more
europepmc   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

Neogene plant macrofossils from West Antarctica reveal persistence of Nothofagaceae forests into the early Miocene. [PDF]

Commun Earth Environ
Bastias-Silva J, Leppe M, Manriquez L, Trevisan C, Fox BRS, Magiera M, Wilson G, Tavazzani L, Chelle-Michou C, Gao L, Szymanowski D, Mansilla H, Silva C, Hervé F, Tapia C.   +14 more
europepmc   +1 more source

Higher interglacial dust fluxes relative to glacial periods in southwestern North American deserts. [PDF]

Nat Commun
Staley SE, Fawcett PJ, Anderson RS, Kirby ME.   +3 more
europepmc   +1 more source

Genomic identification and complete mitochondrial recovery of a Late Holocene porcupine (Erethizon dorsatum) mummy from Yukon permafrost. [PDF]

Sci Rep
Selvatici S, Jin C, Zazula G, Hall E, Hewitson S, Moots HM, Sharif B, Ersmark E, Parducci L, Dalén L, Díez-Del-Molino D, Oteo-García G.   +11 more
europepmc   +1 more source

Assessing climate-driven shifts in Liquidambar orientalis using ensemble species distribution models in the Eastern Mediterranean Region. [PDF]

BMC Plant Biol
Koç DE, Biltekin D, Ustaoğlu B.
europepmc   +1 more source

Quaternary tufas of the western Potiguar Basin, Brazil: rapid xeromorphic adaptation and climate change inferred from sedimentology, paleobotany, and fossil diagenesis. [PDF]

Naturwissenschaften
Aureliano T, Correa L, Ghilardi AM, Erthal M, B Dantas T, C Pontes CC, Lima ML, Maia R, Rusinelli BB, Santiago F, Lima-Filho FP, Ricardi-Branco FS, Bezerra FHR.   +12 more
europepmc   +1 more source