Results 231 to 240 of about 178,686 (262)

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

Tectonism rather than "snowball Earth" glaciation is responsible for the Great Unconformity. [PDF]

Proc Natl Acad Sci U S A
Zhan RR, Duan L, Zattin M, Christie-Blick N, Wan B, Wei RH, Yang Z, Wang J, Gou L, Olivetti V, Chen KY, Zhang X.   +11 more
europepmc   +1 more source

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Late Miocene Arctic warmth and terrestrial climate recorded by North Greenland speleothems. [PDF]

Nat Geosci
Moseley GE, Koltai G, Baker JL, Wang J, Stoll H, Donner A, Friedrich L, Spötl C, Smith MP, Scholz D, Cheng H, Hartland A, Hejny C, Edwards RL.   +13 more
europepmc   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Volcanism-induced collapse and recovery of the Atlantic meridional overturning circulation under glacial conditions. [PDF]

Sci Adv
Vettoretti G, Hu RJ, Bethke I, Krüger K, Sigl M, Outten S, Lin J, Nuterman R, Svensson A, Ditlevsen P, Jochum M.   +10 more
europepmc   +1 more source

Uncooling the planet: Rewilding for function in a post-Pleistocene climate. [PDF]

Camb Prism Extinct
Brook BW, Midgley GF.
europepmc   +1 more source

A Recent Lineage Split in <i>Cladium mariscus</i> Preceding the Disjunction of Two Biodiversity Hotspots: Evidence From Plastid Genomes. [PDF]

Ecol Evol
Qian XH, Yue LL.
europepmc   +1 more source

The last glacial inception in continental northwestern Europe : characterization and timing of the Late Eemian Aridity Pulse (LEAP) recorded in multiple Belgian speleothems [PDF]

, 2017
Blamart, Dominique, Cheng, Hai, Cnudde, Veerle, Deprez, Maxim, Edwards, R Lawrence, Genty, Dominique, non-UU output of UU-AW members, Quinif, Yves, Van Stappen, Jeroen, Vansteenberge, Stef, Verheyden, Sophie   +10 more
core   +1 more source

The Japanese Archipelago sheltered cave lions, not tigers, during the Late Pleistocene. [PDF]

Proc Natl Acad Sci U S A
Sun X, Peng L, Tsutaya T, Jiangzuo Q, Hasegawa Y, Hou Y, Han Y, Zhuang Y, Ramos Madrigal J, Taurozzi AJ, Mackie M, Trochė G, Olsen JV, Cappellini E, O'Brien SJ, Gilbert MTP, Yamaguchi N, Luo SJ.   +17 more
europepmc   +1 more source