Results 201 to 210 of about 21,023 (264)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Relatively warm deep-water formation persisted in the Last Glacial Maximum. [PDF]

Nature
Wharton JH, Kozikowska E, Keigwin LD, Marchitto TM, Maslin MA, Ziegler M, Thornalley DJR.   +6 more
europepmc   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Phylogenetic and Environmental Insights Into the Biogeography of the Western Blacknose Dace, <i>Rhinichthys obtusus</i>. [PDF]

Ecol Evol
Rodriguez A, Earley TS, Taylor S, Dowling TE, Harris PM, Wright J, Machado-Allison A, Chernoff B.   +7 more
europepmc   +1 more source

Early Holocene vigorous Black Sea outflow and the onset of sluggish Aegean deep-water convection. [PDF]

Commun Earth Environ
Evangelinos D, Campderrós S, Trias-Navarro S, Garcia Briña C, Paredes Paredes E, Pena LD, Frigola J, Hasiotis T, Rousakis G, Sakellariou D, Cacho I.   +10 more
europepmc   +1 more source

Pleistocene Legacies in the Contemporary Population Genetic Structure of an Acid-Specialised Crayfish, the Threatened Sand Yabby <i>Cherax robustus</i>. [PDF]

Ecol Evol
Smith G, Ventura T, Yule CM.
europepmc   +1 more source

Population genomics reveals population structure, glacial divergence, and intertidal adaptation in the Chinese chiton (Liolophura sinensis). [PDF]

Commun Biol
Rusitanmu D, Li L, Wan Q, Qi J, Han J.
europepmc   +1 more source

Postglacial genetic legacies and climate-driven demography inform conservation of silver fir. [PDF]

Ann Bot
Balao F, Ríos-Cadenas M, Sánchez-Robles JM, Lorenzo MT, Linares JC, Terrab A.   +5 more
europepmc   +1 more source