Results 41 to 50 of about 20,579 (263)

Sociodemographic Factors Associated With Later Stage at Diagnosis of Pediatric Germ Cell Tumors: A Report From Children's Oncology Group Registries ACCRN07 and APEC14B1

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Germ cell tumors (GCTs) often arise in the ovaries and testes (extracranial) but can also develop in the brain (intracranial). We examined the relationship of individual, family, and community‐level socioeconomic status (SES) with stage of disease at diagnosis in a cohort of pediatric patients with GCT from Children's Oncology Group
Heydon K. Kaddas, Judy Y. Ou, Todd Alonzo, Logan G. Spector, Negar Fallahazad, Emily Owens, Anne C. Kirchhoff, Adam L. Green   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PALEOGEOGRAPHY OF THE ZAONEZHYE PENINSULA IN THE LATE PLEISTOCENE AND HOLOCENE

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015
The paper summarizes the results of long-term paleogeographical research of the Zaonezhye Peninsula conducted by the staff of the Institute of Biology and Institute of Geology of the Karelian Research Centre RAS, including the authors of the article. The
Lyudmila Filimonova, Nadezhda Lavrova
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

LAKE ONEGO LEVEL CHANGES IN THE LATE AND POSTGLACIAL TIMES AS INFERRED FROM THE STUDY OF THE SEDIMENT SEQUENCE ON BOLSHOY KLIMENETSKY ISLAND

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018
The paper presents and discusses the results of the lithological, chronological and bio­stratigraphic study of the sediment sequence on Bolshoy Klimenetsky Island, the larg­est island within the Kizhi Archipelago.
Anna Ludikova, Denis Kuznetsov
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Late Glacial deglaciation of the Zackenberg area, NE Greenland

Geomorphology, 2022
The Greenland Ice Sheet (GrIS) is a key component of the global climate system. However, our current understanding of the spatio-temporal oscillations and landscape transformation of the GrIS margins since the last glacial cycle is still incomplete.
Garcia-Oteyza, J., Oliva, M., Palacios, D., Fernández-Fernández, J.M., Schimmelpfennig, I., Andrés, N., Antoniades, D., Christiansen, H.H., Humlum, O., Leanni, L., Jomelli, V., Ruiz-Fernández, J., Keddadouche, Karim, Rinterknecht, V.R., Lane, T.P., Adamson, K., Aumaître, G., Bourles, D.L.   +17 more
openaire   +8 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Diverse phenotypes of Late Glacial–Early Holocene downy birch (Betula pubescens Erh.) and the morphology of early Preboreal tree stands in southern Schleswig-Holstein [PDF]

Eiszeitalter und Gegenwart
The flexibility in growth of Betula pubescens is taken as example for possible erroneous imaginations of Late Glacial–Early Holocene living conditions.
S. Krüger
doaj   +1 more source