Results 61 to 70 of about 1,748,641 (295)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Eastern Mediterranean surface water temperatures and d18O composition during deposition of sapropels in the late Quaternary [PDF]

, 2003
Water column stratification increased at climatic transitions from cold to warm periods during the lateQuaternary and led to anoxic conditions and sapropel formation in the deep eastern Mediterranean basins.
Struck, U., Erlenkeuser, H., Emeis, K.C., Rossignol-Strick, M., Howell, M. W., Emeis, K.-C., Oba, T., Kroon, Dirk, Schulz, H., Kroon, D., Mackensen, Andreas, Sakamoto, T., Emeis, K. C., Koizumi, I., Ishizuka, S., Mackensen, A., Howell, M.W.   +16 more
core   +3 more sources

LAKE ONEGO LEVEL CHANGES IN THE LATE AND POSTGLACIAL TIMES AS INFERRED FROM THE STUDY OF THE SEDIMENT SEQUENCE ON BOLSHOY KLIMENETSKY ISLAND

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018
The paper presents and discusses the results of the lithological, chronological and bio­stratigraphic study of the sediment sequence on Bolshoy Klimenetsky Island, the larg­est island within the Kizhi Archipelago.
Anna Ludikova, Denis Kuznetsov
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Late Glacial and Holocene shore-level changes in the Aarhus Bugt area, Denmark

GEUS Bulletin, 2021
We propose a new relative shore-level curve for the Aarhus Bugt area, an embayment in eastern Jylland, Denmark, based on a compilation of published and new radiocarbon ages of organic material.
Ole Bennike, Katrine Juul Andresen, Peter Moe Astrup, Jesper Olsen, Marit-Solveig Seidenkrantz   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Late Glacial deglaciation of the Zackenberg area, NE Greenland

Geomorphology, 2022
The Greenland Ice Sheet (GrIS) is a key component of the global climate system. However, our current understanding of the spatio-temporal oscillations and landscape transformation of the GrIS margins since the last glacial cycle is still incomplete.
Garcia-Oteyza, J., Oliva, M., Palacios, D., Fernández-Fernández, J.M., Schimmelpfennig, I., Andrés, N., Antoniades, D., Christiansen, H.H., Humlum, O., Leanni, L., Jomelli, V., Ruiz-Fernández, J., Keddadouche, Karim, Rinterknecht, V.R., Lane, T.P., Adamson, K., Aumaître, G., Bourles, D.L.   +17 more
openaire   +8 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Synoptic climate change as a driver of late Quaternary glaciations in the mid-latitudes of the Southern Hemisphere [PDF]

Climate of the Past, 2006
The relative timing of late Quaternary glacial advances in mid-latitude (40-55° S) mountain belts of the Southern Hemisphere (SH) has become a critical focus in the debate on global climate teleconnections.
H. Rother, J. Shulmeister
doaj