Results 41 to 50 of about 20,556 (264)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PALEOGEOGRAPHY OF THE ZAONEZHYE PENINSULA IN THE LATE PLEISTOCENE AND HOLOCENE

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015
The paper summarizes the results of long-term paleogeographical research of the Zaonezhye Peninsula conducted by the staff of the Institute of Biology and Institute of Geology of the Karelian Research Centre RAS, including the authors of the article. The
Lyudmila Filimonova, Nadezhda Lavrova
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

LAKE ONEGO LEVEL CHANGES IN THE LATE AND POSTGLACIAL TIMES AS INFERRED FROM THE STUDY OF THE SEDIMENT SEQUENCE ON BOLSHOY KLIMENETSKY ISLAND

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018
The paper presents and discusses the results of the lithological, chronological and bio­stratigraphic study of the sediment sequence on Bolshoy Klimenetsky Island, the larg­est island within the Kizhi Archipelago.
Anna Ludikova, Denis Kuznetsov
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Late Glacial deglaciation of the Zackenberg area, NE Greenland

Geomorphology, 2022
The Greenland Ice Sheet (GrIS) is a key component of the global climate system. However, our current understanding of the spatio-temporal oscillations and landscape transformation of the GrIS margins since the last glacial cycle is still incomplete.
Garcia-Oteyza, J., Oliva, M., Palacios, D., Fernández-Fernández, J.M., Schimmelpfennig, I., Andrés, N., Antoniades, D., Christiansen, H.H., Humlum, O., Leanni, L., Jomelli, V., Ruiz-Fernández, J., Keddadouche, Karim, Rinterknecht, V.R., Lane, T.P., Adamson, K., Aumaître, G., Bourles, D.L.   +17 more
openaire   +8 more sources

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Diverse phenotypes of Late Glacial–Early Holocene downy birch (Betula pubescens Erh.) and the morphology of early Preboreal tree stands in southern Schleswig-Holstein [PDF]

Eiszeitalter und Gegenwart
The flexibility in growth of Betula pubescens is taken as example for possible erroneous imaginations of Late Glacial–Early Holocene living conditions.
S. Krüger
doaj   +1 more source

Late Glacial and Holocene shore-level changes in the Aarhus Bugt area, Denmark

GEUS Bulletin, 2021
We propose a new relative shore-level curve for the Aarhus Bugt area, an embayment in eastern Jylland, Denmark, based on a compilation of published and new radiocarbon ages of organic material.
Ole Bennike, Katrine Juul Andresen, Peter Moe Astrup, Jesper Olsen, Marit-Solveig Seidenkrantz   +4 more
doaj   +1 more source