Results 141 to 150 of about 1,710,497 (241)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

How climate, Indigenous people, and fire shaped Brazil's Araucaria Forests through the Late Holocene. [PDF]

Sci Rep
Wilson OJ, Cárdenas ML, Latorre C, Behling H, Davies CA, Iriarte J, Mayle FE.   +6 more
europepmc   +1 more source

Middle to late Holocene plant cover variation in relation to climate, fire, and human activity in the Songnen grasslands of northeastern China. [PDF]

Front Plant Sci, 2022
Niu H, Marquer L, Sack D, Gao G, Wang J, Meng M, Jie D.   +6 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Population Collapse of the Spidery Wattle (<i>Acacia araneosa</i>) During Late Holocene Aridification: Genomic Evidence for Critically Endangered Status. [PDF]

Ecol Evol
Hogben BP, Lowe AJ, Hampel C, Littmann L, O'Leary M, Dorey JB, Blyth C.   +6 more
europepmc   +1 more source

Enhanced North Pacific subtropical gyre circulation during the late Holocene. [PDF]

Nat Commun, 2021
Zhang Y, Zheng X, Kong D, Yan H, Liu Z.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A millennium of cold-water coral habitat loss in the East Pacific during low ENSO variability in the mid- to late Holocene. [PDF]

Proc Natl Acad Sci U S A
Stewart JA, Robinson LF, Taylor ML, Fornari DJ, Robert K, Banks S, Chen T, Li T, Kershaw J, Hoy S, Liu Q, Gordon JD, de Carvalho Ferreira ML, Samperiz A, Shen Y, Sun YJ, Wang M.   +16 more
europepmc   +1 more source

Living on the edge: environmental variability of a shallow late Holocene cold-water coral mound. [PDF]

Coral Reefs, 2022
Raddatz J, Liebetrau V, Rüggeberg A, Foubert A, Flögel S, Nürnberg D, Hissmann K, Musiol J, Goepfert TJ, Eisenhauer A, Dullo WC.   +10 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source