Results 41 to 50 of about 340,011 (295)

Profound anterograde amnesia following routine anaesthetic and dental procedure: a new classification of amnesia characterised by intermediate-to-late stage consolidation failure?

, 2015
Anterograde amnesia caused by bilateral hippocampal or diencephalon damage manifests in characteristic symptoms of preserved intellect and implicit learning, and short span of awareness with complete and rapid forgetting of episodic material.
Burgess, J., Chadalavada, B.
core   +1 more source

Related to Fig 2: Differential expression of intermediate and late temporal TFs in scRNAseq data from the late forebrain and midbrain.

, 2021
(A, F) UMAP plots from late midbrain (A) and forebrain (F) neurons (e16–e18) color coded for the developmental stage from which these cells were obtained.
Thomas Watson (633438), Isabel Zhang (11690157), Jorge Lazaro (11690160), Manuela Melchionda (4813842), James Briscoe (34194), Andreas Sagner (742922)   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Comparative Evaluation of Fusion Strategies Using Multi-Pretrained Deep Learning Fusion-Based (MPDLF) Model for Histopathology Image Classification

Applied Sciences
Histopathological image analysis remains the cornerstone of cancer diagnosis; however, manual assessment is challenged by stain variability, differences in imaging magnification, and complex morphological patterns.
Fatma Alshohoumi, Abdullah Al-Hamdani
doaj   +1 more source

Current evidence for moderate and ultra-hypofractionated radiation therapy in prostate cancer: a summary of the results from phase 3 randomised trials

Scandinavian Journal of Urology, 2023
Problem: A low α/β ratio for prostate cancer (PCa) compared to surrounding normal tissue theoretically implies therapeutical advantages with hypofractionated treatment. Data from large randomised control trials (RCTs) comparing moderate hypofractionated
Oscar Lilleby, Peter Meidahl Petersen, Gedske Daugaard, Katharina Anne Perell   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Late-onset intermediate syndrome due to organophosphate poisoning [PDF]

Clinical Toxicology, 2007
[No abstract available]
Yardan, Turker, Baydin, Ahmet, Aygun, Dursun, Karatas, Aydin Deniz, Deniz, Turgut, Doganay, Zahide   +5 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of timing of surgery on postoperative complications and prognosis in elderly patients with hip fractures

Frontiers in Medicine
BackgroundIn clinical practice, there is no standardized criteria for the optimal timing of hip fracture surgery in the elderly, and there is much controversy.ObjectivesTo investigate the effect of timing of surgery on postoperative complications and ...
Zuobin Zhuo, Weijun Hong, Guangxi Ma
doaj   +1 more source

Columbamine, the central intermediate in the late stages of protoberberine biosynthesis [PDF]

Tetrahedron Letters, 1986
Abstract A specific methyltransferase which in the presence of S-adenosylmethionine [SAM] converts columbamine to palmatine has been demonstrated to occur in Berberis cell cultures. The enzyme acts only on the quaternary alkaloid as substrate, not on its tetrahydro derivative, which fact is in sharp contrast to previous claims.
Rüffer, Martina, Zenk, Meinhart H.
openaire   +2 more sources