Results 111 to 120 of about 340,011 (295)

Late postoperative stenosis of the intermediate bile duct

, 1975
Se presentan 3 observaciones de estenosis tardía de la via biliar extrahepática intermedia, consecutivas a operaciones en las cuales la continuidad de la vía biliar no fue interrumpida. Las manifestaciones clínicas aparecidas tardíamente, sugirieron cuadros completamente diferentes a los hallados en el acto operatorio; Todas se trataronde estenosis ...
Bergalli, Luis E., Piacenza, Guillermo, Chifflet, Juan, Gateño, Nisso, Estefan, Alberto, Priario, Julio, Praderi, Raúl C.   +6 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Traumatic Brain Injury Pathophysiology and Treatments: Early, Intermediate, and Late Phases Post-Injury

, 2013
Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in the population. While precise pathological mechanisms are lacking, the growing base of knowledge concerning TBI has put increased emphasis on its understanding ...
Hanna Algattas, Jason Huang
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

H. pylori eradication rate according to timing of therapeutic regimen after ER: a significantly higher eradication rate was achieved with treatment initiated early, compared with intermediate- or late-phase initiation (early, 90.0%; intermediate, 76.2%; late, 72.4%; p <.001).

, 2016
H. pylori eradication rate according to timing of therapeutic regimen after ER: a significantly higher eradication rate was achieved with treatment initiated early, compared with intermediate- or late-phase initiation (early, 90.0%; intermediate, 76.2 ...
Da Hyun Jung (730619), Young Hoon Youn (3098199), Jie-Hyun Kim (730620), Hyojin Park (106505), Cheal Wung Huh (3098205), Jae Jun Park (3098202)   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Geochronology and geochemistry of the Neoproterozoic–Mesozoic intrusive rocks in the Xinlin area, northeastern China: new constraints on the tectonic evolution of the Erguna block

Frontiers in Earth Science
The occurrence of intrusive rocks within the Xinlin area, northeastern China, provides insights into the Neoproterozoic–Mesozoic geodynamic setting of the Erguna block.
Sheng Lu, Sheng Lu, Sheng Lu, Sheng Lu, Chenglu Li, Masroor Alam, Zhichao Song, Xiannan Zhu, Anzong Fu, Wenpeng Yang   +9 more
doaj   +1 more source

Association of Pelvic Lymph Nodes Inclusion with Late Side Effects in Prostate Cancer Patients Undergoing Curative Radiotherapy [PDF]

Objective: Curative radiotherapy is one of the two leading definitive treatment options for prostate cancer, along with surgery. The inclusion of pelvic lymph nodes in curative radiotherapy for prostate cancer is controversial.
Mustafa Seyyar, Sıtkı Utku Akay
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source