Results 21 to 30 of about 321,360 (252)

Concordance of Chronotype Categorisations Based on Dim Light Melatonin Onset, the Morningness-Eveningness Questionnaire, and the Munich Chronotype Questionnaire

Clocks & Sleep, 2021
Chronotype reflects circadian timing and can be determined from biological markers (e.g., dim light melatonin onset; DLMO), or questionnaires (e.g., Morningness-Eveningness Questionnaire; MEQ, or Munich Chronotype Questionnaire; MCTQ).
Andrew M. Reiter, Charli Sargent, Gregory D. Roach   +2 more
doaj   +1 more source

Long-term outcomes of delayed clozapine initiation in treatment-resistant schizophrenia: a multicenter retrospective cohort study

BMC Psychiatry, 2023
Background Clozapine is the only antipsychotic medication with proven efficacy against treatment-resistant schizophrenia. This multicenter retrospective cohort study aimed to evaluate the impact of a delay in clozapine initiation on long-term outcomes ...
Masakazu Hatano, Hiroyuki Kamei, Ippei Takeuchi, Kazuhiko Gomi, Takashi Sakakibara, Shogo Hotta, Satoru Esumi, Kiyotaka Tsubouchi, Yoshihito Shimizu, Shigeki Yamada   +9 more
doaj   +1 more source

Late-onset Huntington disease with intermediate CAG repeats: true or false? [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2010
Huntington disease (HD) is a neurodegenerative disorder associated with an expanded CAG trinucleotide repeat length in the huntingtin gene. 'Intermediate alleles' with 27 to 35 CAG repeats generally do not cause HD but are unstable upon germ-line transmission.
Groen, J.L., de Bie, R.M.A., Foncke, E.M.J., Roos, R.A.C., Leenders, K.L., Tijssen, M.A.J.   +5 more
openaire   +3 more sources

Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates

ACS Catalysis, 2022
A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates.
Tilby, M, Dewez, D, Pantaine, L, Hall, A, Martinez-Lamenca, C, Willis, M   +5 more
openaire   +4 more sources

Micronutrient Accumulation in Conilon Coffee Berries with Different Maturation Cycles

Revista Brasileira de Ciência do Solo, 2015
The number of days between anthesis and maturation of conilon coffee berries varies according to the genotype. Thus, it is believed that periods of greater nutrient demand for fruit formation also vary according to the genotype, directly influencing ...
Wellington Braida Marré, Fábio Luiz Partelli, Marcelo Curitiba Espindula, Jairo Rafael Machado Dias, Ivoney Gontijo, Henrique Duarte Vieira   +5 more
doaj   +1 more source

Oromandibular Dyskinesia as the Initial Manifestation of Late-Onset Huntington Disease [PDF]

Journal of Movement Disorders, 2011
Huntington’s disease (HD) is a neurodegenerative disorder characterized by a triad of choreoathetosis, dementia and dominant inheritance. The cause of HD is an expansion of CAG trinucleotide repeats in the HD gene.
Dong-Seok Oh, Eun-Seon Park, Seong-Min Choi, Byeong-Chae Kim, Myeong-Kyu Kim, Ki-Hyun Cho   +5 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

The star formation history of intermediate-redshift late-type galaxies [PDF]

Monthly Notices of the Royal Astronomical Society, 2004
We combine the latest observations of disk galaxy photometry and rotation curves at moderate redshift from the FORS Deep Field (FDF) with simple models of chemical enrichment. Our method describes the buildup of the stellar component through infall of gas and allows for gas and metal outflows.
Ferreras, Ignacio, Silk, Joseph, Böhm, Asmus, Ziegler, Bodo   +3 more
openaire   +4 more sources

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Observing a late folding intermediate of Ubiquitin at atomic resolution by NMR [PDF]

Protein Science, 2016
AbstractThe study of intermediates in the protein folding pathway provides a wealth of information about the energy landscape. The intermediates also frequently initiate pathogenic fibril formations. While observing the intermediates is difficult due to their transient nature, extreme conditions can partially unfold the proteins and provide a glimpse ...
Parag Surana, Ranabir Das
openaire   +2 more sources