Results 21 to 30 of about 2,703,108 (241)

Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland.

PLoS Medicine, 2020
BackgroundVery few studies have explored the patterns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia. We examined the associations of composite CVH metrics from midlife to late life with risk of incident ...
Yajun Liang, Tiia Ngandu, Tiina Laatikainen, Hilkka Soininen, Jaakko Tuomilehto, Miia Kivipelto, Chengxuan Qiu   +6 more
doaj   +1 more source

One-week vaginal brachytherapy schedule as exclusive adjuvant post-operative treatment in intermediate- and high-intermediate-risk endometrial cancer patients [PDF]

, 2020
Purpose: The aim of the study was to report survival outcomes and toxicities incidence by using one-week vaginal brachytherapy (VBT) schedule in intermediate- and high-intermediate-risk endometrial cancer patients.Material and methods: One hundred and ...
Giovanni Gravina, Mattia Osti, Di Staso, Mario, Giuseppe Facondo, Chalaszczyk, Agnieszka, De Felice, Francesca, Anzellini, Dimitri, Osti, Mattia Falchetto, Gianluca Vullo, Tombolini, Vincenzo, Maria Massaro, Pierluigi Bonfili, Mario Di Staso, Vincenzo Tombolini, Facondo, Giuseppe, Gravina, Giovanni Luca, Marampon, Francesco, Bonfili, Pierluigi, Bonome, Paolo, Agnieszka Chalaszczyk, Valeriani, Maurizio, Vitaliana De Sanctis, Vullo, Gianluca, Dimitri Anzellini, De Sanctis, Vitaliana, Massaro, Maria, Maurizio Valeriani, Francesca Felice, Daniela Musio, Francesco Marampon, Musio, Daniela, Paolo Bonome   +31 more
core   +1 more source

Impact of hospitalization duration before medical emergency team activation: A retrospective cohort study.

PLoS ONE, 2021
BackgroundThe rapid response system has been implemented in many hospitals worldwide and, reportedly, the timing of medical emergency team (MET) attendance in relation to the duration of hospitalization is associated with the mortality of MET patients ...
Jinmi Lee, Yujung Shin, Eunjoo Choi, Sunhui Choi, Jeongsuk Son, Youn Kyung Jung, Sang-Bum Hong   +6 more
doaj   +1 more source

Concordance of Chronotype Categorisations Based on Dim Light Melatonin Onset, the Morningness-Eveningness Questionnaire, and the Munich Chronotype Questionnaire

Clocks & Sleep, 2021
Chronotype reflects circadian timing and can be determined from biological markers (e.g., dim light melatonin onset; DLMO), or questionnaires (e.g., Morningness-Eveningness Questionnaire; MEQ, or Munich Chronotype Questionnaire; MCTQ).
Andrew M. Reiter, Charli Sargent, Gregory D. Roach   +2 more
doaj   +1 more source

The human adenovirus 5 L4 promoter is activated by cellular stress response protein p53 [PDF]

, 2013
During adenovirus infection, the emphasis of gene expression switches from early genes to late genes in a highly regulated manner. Two gene products, L4-22K and L4-33K, contribute to this switch by activating the Major Late Transcription Unit (MLTU) and ...
Leppard, Keith, Wright, Jordan
core   +1 more source

Long-term outcomes of delayed clozapine initiation in treatment-resistant schizophrenia: a multicenter retrospective cohort study

BMC Psychiatry, 2023
Background Clozapine is the only antipsychotic medication with proven efficacy against treatment-resistant schizophrenia. This multicenter retrospective cohort study aimed to evaluate the impact of a delay in clozapine initiation on long-term outcomes ...
Masakazu Hatano, Hiroyuki Kamei, Ippei Takeuchi, Kazuhiko Gomi, Takashi Sakakibara, Shogo Hotta, Satoru Esumi, Kiyotaka Tsubouchi, Yoshihito Shimizu, Shigeki Yamada   +9 more
doaj   +1 more source

Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates

ACS Catalysis, 2022
A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates.
Tilby, M, Dewez, D, Pantaine, L, Hall, A, Martinez-Lamenca, C, Willis, M   +5 more
openaire   +4 more sources

Oromandibular Dyskinesia as the Initial Manifestation of Late-Onset Huntington Disease [PDF]

Journal of Movement Disorders, 2011
Huntington’s disease (HD) is a neurodegenerative disorder characterized by a triad of choreoathetosis, dementia and dominant inheritance. The cause of HD is an expansion of CAG trinucleotide repeats in the HD gene.
Dong-Seok Oh, Eun-Seon Park, Seong-Min Choi, Byeong-Chae Kim, Myeong-Kyu Kim, Ki-Hyun Cho   +5 more
doaj   +1 more source

The star formation history of intermediate-redshift late-type galaxies [PDF]

Monthly Notices of the Royal Astronomical Society, 2004
We combine the latest observations of disk galaxy photometry and rotation curves at moderate redshift from the FORS Deep Field (FDF) with simple models of chemical enrichment. Our method describes the buildup of the stellar component through infall of gas and allows for gas and metal outflows.
Ferreras, Ignacio, Silk, Joseph, Böhm, Asmus, Ziegler, Bodo   +3 more
openaire   +4 more sources

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source