Results 61 to 70 of about 2,703,108 (241)

CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing

Frontiers in Immunology
A balance between pro-inflammatory decidual CD4+ T cells and FOXP3+ regulatory T cells (FOXP3+ Tregs) is important for maintaining fetomaternal tolerance.
Sayaka Tsuda, Sayaka Tsuda, Shigeyuki Shichino, Tamara Tilburgs, Tomoko Shima, Keiko Morita, Akemi Yamaki-Ushijima, Krishna Roskin, Michio Tomura, Azusa Sameshima, Azusa Sameshima, Shigeru Saito, Akitoshi Nakashima   +12 more
doaj   +1 more source

NATURE OF THE LATE CARBONIFEROUS TO TRIASSIC MAGMATISM ALONG THE NORTHERN MARGIN OF THE NORTH CHINA BLOCK: LINK WITH THE EVOLUTION OF THE CENTRAL ASIAN OROGEN

Геодинамика и тектонофизика, 2017
There are two episodes of magmatism along the northern margin of the North China block during the Late Carboniferous to Late Triassic, one at 310–250 Ma (Late Carboniferous to Permian) and the other at 235–210 Ma (Late Triassic).
Peng Peng, Mingguo Zhai, Xiangdong Su, Taiping Zhao, Yanyan Zhou   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Intermediate b final exam v1 [PDF]

, 2010
Written exam for students who have completed Units 8C to 12 in the Face2Face Intermediate Series published by Cambridge University ...
Pedley, Emma
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Multiple logistic regression model to predict intermediate/late AMD (MGS 3 and 4, N = 61) versus controls (MGS 1, N = 53).

, 2021
Multiple logistic regression model to predict intermediate/late AMD (MGS 3 and 4, N = 61) versus controls (MGS 1, N = 53).
Sandra R. Montezuma (3830209), Marcia R. Terluk (11581508), Rebecca J. Kapphahn (8697732), Deborah A. Ferrington (8697738), Timothy W. Olsen (8292615), Karen R. Armbrust (11581502), Pabalu P. Karunadharma (11581505)   +6 more
core   +1 more source

OSTEOFITOSIS VERTEBRAL EN POBLACIONES PREHISPÁNICAS DE SAN PEDRO DE ATACAMA, NORTE DE CHILE

Estudios Atacameños
Se estudió la osteofitosis vertebral como indicador de estrés físico en grupos humanos prehistóricos de San Pedro de Atacama, durante los períodos Medio (400 DC - 1000 DC) e Intermedio Tardío (1000 DC - 1450 DC).
Rocío López-Barrales, Mark Hubbe, Eugenio Aspillaga, Walter A Neves, Hermann M Niemeyer   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Growth Curve Models and Clustering Techniques for Studying New Sugarcane Hybrids

AgriEngineering
Sugarcane (Saccharum spp.) is a crop of significant industrial and nutritional value, essential for producing various products. Due to its importance, genetic improvement programs involve a rigorous selection process.
Carlos David Carretillo Moctezuma, María Guzmán Martínez, Flaviano Godínez-Jaimes, José C. García-Preciado, Ramón Reyes Carreto, José Terrones Salgado, Edgar Pérez Arriaga   +6 more
doaj   +1 more source