Results 161 to 170 of about 1,282,772 (281)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

GUÁNUCOS OCCUPATION FROM MIDDLE HORIZON PERIOD TO LATE INTERMEDIATE

, 2012
El Alto Marañón fue testigo de varios grupos culturales que tuvieron una prolongada ocupación. Aquí se aborda sobre uno de ellos, los Guánuco, que han sido objeto de análisis por los historiadores y confundidos como parte de un presunto Imperio Yarowilca y que ha conllevado a errores de percepción de lo que fueron en realidad, una nación con diferentes
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Divergent synthesis of Haplomitrium diterpenoids via a late-stage biomimetic skeletal reorganization approach. [PDF]

Nat Commun
Gao ZX, Su C, Zhang HX, Zhang YQ, Chen XX, Liu XY, Cheng AX, Xu ZJ, Lou HX.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The best from both disciplines: integrating human and microbial signatures from whole genome sequencing to advance cancer diagnostics. [PDF]

mSystems
Moser T, Moser MJ, Mahnert A.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Prediction of late ventricular arrhythmias in patients with left ventricular assist device: insights from the VT-LVAD consortium. [PDF]

Europace
Martins R, Galand V, Flecher E, Groussin P, Bode K, Efimova E, Dashkevich A, Liang J, Larson J, Mondesert B, Boulet J, Noly PE, Sacher F, Pasquié JL, Gourraud JB, Ninni S, Jesel L, Sebestyen A, Algalarrondo V, Deharo JC, Anselme F, Champ-Rigot L, Guenancia C, Pierre B, Eschalier R, Echivard M, Baudinaud P, Lellouche N, Gardey K, Benali K, Gautier P, Delmas C, Cherbi M.   +32 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Risks and Benefits of Vesicoamniotic Shunting for Lower Urinary Tract Obstruction (LUTO) After Early, Intermediate and Late Onset of Therapy-A Monocentric Study of 104 Treated Cases. [PDF]

Biomedicines
Riehle N, Kohl T.
europepmc   +1 more source