Results 61 to 70 of about 2,746,446 (292)

CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing

Frontiers in Immunology
A balance between pro-inflammatory decidual CD4+ T cells and FOXP3+ regulatory T cells (FOXP3+ Tregs) is important for maintaining fetomaternal tolerance.
Sayaka Tsuda, Sayaka Tsuda, Shigeyuki Shichino, Tamara Tilburgs, Tomoko Shima, Keiko Morita, Akemi Yamaki-Ushijima, Krishna Roskin, Michio Tomura, Azusa Sameshima, Azusa Sameshima, Shigeru Saito, Akitoshi Nakashima   +12 more
doaj   +1 more source

La cerámica de Coscopunta, un sitio del Periodo Intermedio Tardío en la provincia de Carhuaz, Callejón de Huaylas, Perú

Bulletin de l'Institut Français d'Études Andines, 2015
This essay describes a large group of complete or nearly complete Late Intermediate Period pottery vessels uncovered by a farmer in 1979 at the site of Coscopunta, near the town of the Anta, Carhuaz Province, Ancash.
Richard L. Burger, Lucy C. Salazar
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Evaluation of the clinical and cost effectiveness of intermediate care clinics for diabetes (ICCD) : a multicentre cluster randomised controlled trial [PDF]

, 2014
Background: Configuring high quality care for the rapidly increasing number of people with type 2 diabetes (T2D) is a major challenge worldwide for both providers and commissioners.
Joseph Paul O’Hare, P. Saravanan (2679490), Saravanan, Ponnusamy, Baines Darrin, Khunti, Kamlesh, Andrew Wilson, Hardy, Ainsley, Joseph Paul O’Hare (552525), Ala Szczepura (83137), Darrin Baines (552528), Saravanan Ponnusamy, Sudhesh Kumar (89490), O’Hare Joseph Paul, Ric Crossman (552527), Andrew Wilson (23322), Khunti Kamlesh, Kamlesh Khunti, Hardy, Ainslea, Wilson Andrew, Hardy Ainsley, Crossman, Richard, Ala Szczepura, ICCD trial group (7628486), Wilson, Andrew, Crossman Ric, A. Szczepura (7628477), ICCD trial group, Darrin Baines, Ponnusamy Saravanan (552529), Raymond Neil, Raymond, Neil T., J. P. O'Hare (7628471), N. Raymond (7628474), Baines, Darrin L., Ainsley Hardy, Ainsley Hardy (552526), Kumar Sudhesh, Sudhesh Kumar, Baines, Darrin, Joseph Paul O'Hare, Neil Raymond, Neil Raymond (438247), Szczepura, Ala, Crossman, Ric, Kumar, Sudhesh, Kamlesh Khunti (171607), S. Kumar (746162), Raymond, Neil, Szczepura Ala, D. Baines (7628483), R. Crossman (7628480), O’Hare, Joseph Paul, O'Hare, J. Paul, Ric Crossman, Ponnusamy Saravanan   +54 more
core   +1 more source

OSTEOFITOSIS VERTEBRAL EN POBLACIONES PREHISPÁNICAS DE SAN PEDRO DE ATACAMA, NORTE DE CHILE

Estudios Atacameños
Se estudió la osteofitosis vertebral como indicador de estrés físico en grupos humanos prehistóricos de San Pedro de Atacama, durante los períodos Medio (400 DC - 1000 DC) e Intermedio Tardío (1000 DC - 1450 DC).
Rocío López-Barrales, Mark Hubbe, Eugenio Aspillaga, Walter A Neves, Hermann M Niemeyer   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Molecular Architecture of a Late 40S Ribosome Assembly Intermediate [PDF]

Biophysical Journal, 2012
Ribosomes are self-assembling macromolecular machines which catalyze the synthesis of proteins in all cells, and are made up of two subunits that differ in size due to the presence of RNA and proteins in different ratio. Although significant structural details of the organization of mature ribosomes in prokaryotes and eukaryotes have been elucidated in
Vashisth, Dr. Harish, Brooks, Prof. Charles L.   +1 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Intermediate a mid-term exam v1 [PDF]

, 2010
Written exam for students who have completed Units 7A to 11B of the Face2Face Pre-Intermediate Student´s Book published by Cambridge University ...
Pedley, Emma
core