Results 221 to 230 of about 1,282,772 (281)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Outcomes and recurrence pattern analysis of intensity modulated chemoradiotherapy in nasopharyngeal cancer: a retrospective study from Heidelberg University Hospital. [PDF]

Radiat Oncol
Bauer L, Regnery S, Deng MY, Stritzke F, Schröter P, Franke H, Netzer NB, Uzun-Lang K, Weusthof K, Thoelken R, Debus J, Held T.   +11 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Robust Multimodal Fusion for Survival Prediction in Cancer Patients. [PDF]

Cancer Inform
Flack D, Tripathi A, Waqas A, Rasool G, Dera D.   +4 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Modifying effects of compensatory sleep on elevated blood pressure related to school-day sleep patterns. [PDF]

BMC Med
Liu J, Song X, Chen M, Zhang Y, Jiang J, Wang R, Dong Z, Chen L, Qin Y, Guo T, Song Z, Yuan W, Wang X, Ma J, Dong Y, Song Y.   +15 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Alkene Diversification through a Molecular Recasting Strategy Enabled by <i>N</i>-Heterocyclic Carbene and Photoredox Dual Catalysis. [PDF]

Research (Wash D C)
Li QZ, He MH, Wang PT, Xiang DY, Hong LH, Zeng R, Li JL.   +6 more
europepmc   +1 more source

Inverting polarity in a cobalt MHAT reaction <i>via</i> reductive catalytic turnover. [PDF]

Chem Sci
Jana S, Kusza DA, Vystavkin N, Lunic D, Teskey CJ.   +4 more
europepmc   +1 more source

Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence. [PDF]

JHEP Rep
Vu H, Sun Y, Xiong Z, Tan X, Radford-Smith D, Causer A, Dickens AM, Hyötyläinen T, Evstafev I, Oresic M, Nefzger C, O'Sullivan ED, Watt MJ, Ramm GA, Clouston A, Irvine KM, Nguyen QH, Powell EE.   +17 more
europepmc   +1 more source