Results 221 to 230 of about 1,274,726 (282)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer-Aided Drug Design. [PDF]

Int J Microbiol
Zhao L, Qu J, An M, Liu Y, Li X, Liu Y, Peng C.   +6 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Prediction of late ventricular arrhythmias in patients with left ventricular assist device: insights from the VT-LVAD consortium. [PDF]

Europace
Martins R, Galand V, Flecher E, Groussin P, Bode K, Efimova E, Dashkevich A, Liang J, Larson J, Mondesert B, Boulet J, Noly PE, Sacher F, Pasquié JL, Gourraud JB, Ninni S, Jesel L, Sebestyen A, Algalarrondo V, Deharo JC, Anselme F, Champ-Rigot L, Guenancia C, Pierre B, Eschalier R, Echivard M, Baudinaud P, Lellouche N, Gardey K, Benali K, Gautier P, Delmas C, Cherbi M.   +32 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Predictive Processing Over the Course of Aging: Multiple Timescales of Effective Connectivity. [PDF]

Eur J Neurosci
Banaschewski MT, Mathys C, Winkler I, Todd J, Auksztulewicz R.   +4 more
europepmc   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Variability in Post-Discharge Mortality Rates and Predictors over Time: Data from a Five-Year Ward-Wide Study. [PDF]

J Clin Med
Ramirez GA, Germinario BN, Benanti G, Caruso PF, Mette F, Pagliula G, Cariddi A, Sartorelli S, Falbo E, Marinosci A, Farina F, Pacioni G, Rela E, Barbieri P, Tresoldi M, Bozzolo EP.   +15 more
europepmc   +1 more source

Enrichment Characteristics and Genetic Analysis of Rare Earth Elements in the Lower Longtan Formation Coal of Qianbei Coalfield, Guizhou Province. [PDF]

ACS Omega
Li Y, Zhu Y, Yang Z, Wang F, Ding Y, Li B, Yang Y, Hu C.   +7 more
europepmc   +1 more source

Mapping transcriptional patterns of MPXV in human epithelial cells. [PDF]

Emerg Microbes Infect
Picarone L, Pietrucci D, Mariotti D, Milanesi M, Mija C, Bordi L, Meschi S, Mazzotta V, Gruber CEM, Mavian C, Girardi E, Antinori A, Matusali G, Chillemi G, Maggi F.   +14 more
europepmc   +1 more source