Results 41 to 50 of about 321,360 (252)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Life in the late Intermediate Period at Armatambo, Peru [PDF]
, 2018 Title from PDF of title page (University of Missouri--Columbia, viewed on October 18, 2012). ; The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. ; Dissertation advisors: Dr. Robert A. Benfer and Dr. Deborah M. Pearsall ; Vita.
openaire +2 more sources
Columbamine, the central intermediate in the late stages of protoberberine biosynthesis [PDF]
Tetrahedron Letters, 1986 Abstract A specific methyltransferase which in the presence of S-adenosylmethionine [SAM] converts columbamine to palmatine has been demonstrated to occur in Berberis cell cultures. The enzyme acts only on the quaternary alkaloid as substrate, not on its tetrahydro derivative, which fact is in sharp contrast to previous claims.
Rüffer, Martina, Zenk, Meinhart H.
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Accurate Spectroscopy of Intermediate and Late Spectral Types [PDF]
Symposium - International Astronomical Union, 1988 Elemental abundances in the Sun and in meteorites are examined with respect to their qualification as a standard ofpopulation I composition. Some problems that arise in connection with spectroscopic determinations of abundances in the Sun, and in other late-type stars, are discussed with emphasis onphotospheric modelsanddepartures from LTE.
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Геодинамика и тектонофизика, 2017 There are two episodes of magmatism along the northern margin of the North China block during the Late Carboniferous to Late Triassic, one at 310–250 Ma (Late Carboniferous to Permian) and the other at 235–210 Ma (Late Triassic).
Peng Peng +4 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Molecular Architecture of a Late 40S Ribosome Assembly Intermediate [PDF]
Biophysical Journal, 2012 Ribosomes are self-assembling macromolecular machines which catalyze the synthesis of proteins in all cells, and are made up of two subunits that differ in size due to the presence of RNA and proteins in different ratio. Although significant structural details of the organization of mature ribosomes in prokaryotes and eukaryotes have been elucidated in
Vashisth, Dr. Harish +1 more
openaire +1 more source
CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing
Frontiers in ImmunologyA balance between pro-inflammatory decidual CD4+ T cells and FOXP3+ regulatory T cells (FOXP3+ Tregs) is important for maintaining fetomaternal tolerance.
Sayaka Tsuda +12 more
doaj +1 more source