Results 121 to 130 of about 340,011 (295)

Comparison of actual survival among patients with pre-ACLF, early-stage ACLF, intermediate-stage ACLF and late-stage ACLF.

, 2013
No significant differences existed between patients with pre-ACLF and early-stage ACLF (P>0.05). However, the difference in survival between pre-ACLF patients and intermediate-stage ACLF patients was statistically significant ...
Qian Yang (300330), Jianrong Huang (108854), Yuemei Chen (418377), Lanjuan Li (112956), Xiahong Dai (418373), Qi Xia (187080), Yimin Zhang (418374), Yongzheng Guo (418375), Xiaowei Xu (82471), Weibo Du (418376), Xiaoli Liu (165371)   +10 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The evolution of large-bodied theropod dinosaurs during the Mesozoic in Asia

, 2010
The fossil record of large-bodied, apex carnivorous theropod dinosaurs in Eastern Asia is now among the best understood in the world, thanks to new discoveries and reinterpretations of long-neglected fossils.
Benson, R. B. J., Brusatte, S. L., S. L. Brusatte, Brusatte, SL, Brusatte, S. L.; id_orcid, Xu, X., Xu, X, X. Xu, Benson, RBJ, R. B. J. Benson   +9 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Examining the Efficacy and Safety of Combined Locoregional Therapy and Immunotherapy in Treating Hepatocellular Carcinoma

Biomedicines
More than 800,000 people worldwide are diagnosed with HCC (hepatocellular carcinoma) each year, with approximately 700,000 deaths alone occurring in that same year.
Nojan Bajestani, Gavin Wu, Ahmed Hussein, Mina S. Makary   +3 more
doaj   +1 more source

Intermediate and deep water paleoceanography of the northern North Atlantic over the past 21,000 years

Benthic foraminiferal stable isotope records from four high-resolution sediment cores, forming a depth transect between 1237 m and 2303 m on the South Iceland Rise, have been used to reconstruct intermediate and deep water paleoceanographic changes in ...
Thornalley, David. J. R., Elderfield, Harry, McCave, I. Nick   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Late Quaternary changes in intermediate water oxygenation and oxygen minimum zone, northern Japan: A benthic foraminiferal perspective

, 2007
A strong oxygen minimum zone (OMZ) currently exists at upper intermediate water depths on the northern Japanese margin, NW Pacific. The OMZ results largely from a combination of high surface water productivity and poor ventilation of upper intermediate ...
Kennett, James P., Shibahara, Akihiko, Ikehara, Ken, Ohkushi, Ken'Ichi   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Stellar Mass Functions of Early and Late-Type Galaxies in Groups at Intermediate Redshifts

, 2009
We study the stellar mass functions of early and late-type galaxies in a galaxy group system at a redshift of z=0.37 in order to investigate mass assembly histories in a type of rarely explored galaxy systems at intermediate redshifts which are ...
Kautsch, Stefan, Gonzalez, Anthony H.
core