Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism. [PDF]
Thomson BD +5 more
europepmc +1 more source
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Late Holocene mud sedimentation and diagenesis in the Firth of Thames: Bentonites in the making
Late Holocene mud sedimentation in the southern Firth of Thames has been described from analysis of a number of shallow marine sediment cores. Three distinct lithofacies are distinguished on the basis of sediment texture and mineralogy.
Naish, Timothy R.
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Timing of intervention in cardiogenic shock management: A systematic review and network meta-analysis. [PDF]
Popat A, Yadav S.
europepmc +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Establishment of Three Different Glycation-Damage Cell Models and Analysis of Their Action Mechanism. [PDF]
Qian X, Cao C, Liu L.
europepmc +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Lineage tracing reveals photoreceptor precursor cell subpopulations that contribute to murine retinogenesis. [PDF]
Yano JJ +5 more
europepmc +1 more source
Includes bibliographical references.The study sites investigated in this thesis are situated along the southwest coast of South Africa in an area dominated by the sclerophyllous fynbos of the Strandveld and Sandveld, which supports a well-known ...
Matthews, Thalassa
core

