Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Differential role of beta band activity in a dual-task working memory paradigm under internally vs. externally directed cognition. [PDF]
Front Hum NeurosciYadav A, Banerjee A, Roy D.
europepmc +1 more source
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Acute and late toxicity in prostate cancer patients treated with moderately vs ultra-hypofractionated radiotherapy. [PDF]
Front OncolCifuentes-Quin J +7 more
europepmc +1 more source
Cardiac arrest secondary to mitral annular disjunction: a case report. [PDF]
Eur Heart J Case RepSmman A, Meurgey JH, Khiani R, Amaral N.
europepmc +1 more source
Survival and Safety Outcomes of Three-Cycle Adjuvant Chemotherapy in Intermediate-Risk Endometrial Cancer. [PDF]
Cancers (Basel)Higami S, Kinjo Y, Kurita T, Yoshino K.
europepmc +1 more source
Risk factors for recurrent falls in midlife: a prospective cohort study using data from the Health and Employment After Fifty (HEAF) study. [PDF]
BMJ OpenD'Angelo S +4 more
europepmc +1 more source
Soil microbial communities and carbon and nitrogen forms across snow-driven vegetation types in alpine tundra. [PDF]
Front MicrobiolBenech A +7 more
europepmc +1 more source
B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed Chemical Tagging of Bioactive <i>N</i>-Alkylamines through β-Amino C(sp<sup>3</sup>)-H Functionalization. [PDF]
Org LettChapman M +6 more
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BIOLOGICAL CHLORINATION. VIII. LATE INTERMEDIATES IN THE BIOSYNTHESIS OF CALDARIOMYCIN.
The Journal of biological chemistry, 1996 J R, BECKWITH, L P, HAGER
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