Results 51 to 60 of about 165,268 (253)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tradiciones alfareras, identidad social y el concepto de etnias tardías en Conchucos, Ancash, Perú

Bulletin de l'Institut Français d'Études Andines, 2009
This article explores the issues of social identity, Late Intermediate Period ethnic groups and sociopolitical divisions in relation to the ceramic traditions observed in southern and central Conchucos.
Isabelle Druc
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Late Intermediate Period in Cajamarquilla from the evidence of the Tello sector

Arqueología y Sociedad, 2021
El presente artículo aborda la problemática de la ocupación del Periodo Intermedio Tardío en el sitio arqueológico de Cajamarquilla, ubicado dentro de la ciudad de Lima Metropolitana, uno de los asentamientos más extensos de la costa de Lima, pero a la vez uno de los menos investigados.
openaire   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

BILE DUCT INJURIES AND OUTCOMES: A RETROSPECTIVE MEDICAL RECORD REVIEW

Pakistan Armed Forces Medical Journal, 2017
Objective: To report on our experience of cholecystectomy associated bile duct injuries and observe factors influencing outcomes. Study Design: Simple descriptive study.
Adeel Qamar Ghumman, Maqbool Ahmad, Aurangzeb Khan, Zafar Iqbal Gondal, Zaka Ullah Malik, Manan Masud   +5 more
doaj   +2 more sources

Morpho-agronomic performance of vetch species and their accessions grown under nitosol and vertisol conditions in the central highlands of Ethiopia

Agriculture & Food Security, 2018
Background Vetch is one of the promising forage legumes to mitigate the existing critical feed shortage problem in the Ethiopian highlands. The study was conducted to describe the morphological and agronomical traits and to examine the performances of ...
Gezahagn Kebede
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Iconographic Similarities Between Permian “Goddess Plaques” (Ural Region, 7-8th Centuries CE) and Horus Cippi (Egypt, 8th Century BCE - 2nd Century CE)

Eikón Imago, 2020
The iconography of the Horus cippus, an amulet popular in Egypt from the late Third Intermediate Period to Roman times (8thcentury BCE - 2nd century CE), is unexpectedly recapitulated in bronze “goddess plaques” of the 7-8th centuries CE made by Permian ...
Lloyd D. Graham
doaj   +1 more source