Results 81 to 90 of about 7,286,898 (204)

Comparisons of the demographic findings among early treatment, intermediate treatment, and late treatment groups.

open access: yes, 2016
Comparisons of the demographic findings among early treatment, intermediate treatment, and late treatment groups.
Da Hyun Jung (730619)   +5 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

La vestimenta femenina en la Costa Central del Perú durante el Período Intermedio Tardío

open access: yesEstudios Atacameños, 2000
Los vestidos femeninos del Período Intermedio Tardío (1000 - 1470 DC) hallados en la Costa Central peruana se definen por la posición horizontal de las aberturas para los brazos y la cabeza, a diferencia de las aberturas verticales de los trajes ...
Delia Aponte
doaj   +1 more source

Intermediate Inflation or Late Time Acceleration? [PDF]

open access: yes, 2008
The expansion rate of “intermediate inflation” lies between the exponential and power law expansion but corresponding accelerated expansion does not start at the onset of cosmological evolution.
Abhik Kumar Sanyal
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Cambios y continuidades en el valle de Lurín a la llegada de los incas: el caso de Pampa de Flores

open access: yesBulletin de l'Institut Français d'Études Andines, 2017
This research explores the continuity, transformation and changes that occurred in the Late Intermediate Period monumental architecture of the Lurin Valley with the arrival of the Incas, and the consequences that had on its social and political ...
Camila Capriata Estrada   +1 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

El fenómeno “pucara” visto desde la puna jujeña

open access: yesEstudios Atacameños, 1997
En los Andes Centro Sur el uso del término pucara es ambiguo, dado que se lo utiliza para denominar tanto fortalezas, poblados fortificados, asentamientos naturalmente inexpugnables o sitios estratégicos que controlan recursos o vías de circulación ...
Marta Ruiz, María Ester Albeck
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

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