Results 61 to 70 of about 7,190,038 (290)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Coexistence, contacts and conflicts in the precordillera of Tacna during the Late Intermediate Period (AD 1100-1450)

Bulletin de l'Institut Français d'Études Andines
The precordillera of Tacna, between the communities of Sitajara and Tarata, has long had the reputation of being a zone of cohabitation between local, altiplano and coastal populations.
Romuald Housse
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Characteristics of rainfall and erosion under natural conditions of land use in semiarid regions

Revista Brasileira de Engenharia Agrícola e Ambiental, 2013
The characteristics of rainfall can provide important information for management and land use may also minimize the water erosion problems. This study was carried out to evaluate soil and water loss in erosion plots with different coverage, and the ...
Cleene A. de Lima, Helba A. de Q. Palácio, Eunice M. de Andrade, Julio C. N. dos Santos, Paulilo P. Brasil   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

RELACIONES CERÁMICAS Y SOCIALES ENTRE SAN PEDRO DE ATACAMA Y EL LOA SUPERIOR DURANTE EL PERÍODO INTERMEDIO TARDÍO A TRAVÉS DEL ANÁLISIS DE FLUORESCENCIA DE RAYOS X PORTÁTIL

Estudios Atacameños
Durante el período Intermedio Tardío las comunidades de San Pedro de Atacama y del Loa Superior produjeron tipos cerámicos similares. La cerámica, junto a otros materiales, sugieren una intensificación de una identidad regional compartida durante este ...
Emily Stovel, William Whitehead, Michael Deibel, Mauricio Uribe   +3 more
doaj   +1 more source

Intensity modulated radiotherapy (IMRT) or conformational radiotherapy (3D-CRT) with conventional fractionation for prostate cancer: Is there any clinical difference? [PDF]

International Brazilian Journal of Urology
Purpose: To compare the treatment outcomes of a cohort of prostate cancer patients treated with conventional schedule using IMRT or 3DRT technique.
Gustavo Viani, Ana Carolina Hamamura, Alexandre C. Faustino   +2 more
doaj   +2 more sources

Early recurrence during the blanking period and left atrial reverse remodeling after catheter ablation for non-paroxysmal atrial fibrillation

International Journal of Cardiology: Heart & Vasculature, 2020
Background: Early recurrence of atrial tachyarrhythmia (ERAT) during a 90-day blanking period (BP) often occurs after atrial fibrillation (AF) ablation. Left atrial reverse remodeling (LARR), which is the reduction in LA volume (LAV), also occurs during ...
Takafumi Oka, Yasushi Koyama, Koji Tanaka, Yuko Hirao, Nobuaki Tanaka, Masato Okada, Issei Yoshimoto, Ryo Kitagaki, Atsunori Okamura, Katsuomi Iwakura, Yasushi Sakata, Kenshi Fujii, Koichi Inoue   +12 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Acerca de complejidad, desigualdad social y el complejo cultural Pica-Tarapacá en los Andes Centro-Sur (1000-1450 DC)

Estudios Atacameños
El propósito principal de este trabajo es revisar los conceptos de complejidad y desigualdad social, intentando comprender arqueológicamente los sistemas que desarrollaron las poblaciones de los Andes Centro-Sur durante el Período Intermedio Tardío, en ...
Mauricio Uribe R
doaj   +1 more source