Results 101 to 110 of about 126,063 (304)

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren [PDF]

, 2010
<STRONG>Background</STRONG> Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN).
A Brady, AL Rickards, AT Bhutta, BE Stephens, CM McCarton, D Wolke, Daniel F. MacKay, G Wiener, Gordon C. S. Smith, I Kirkegaard, J Briscoe, J Cuzick, Jill P. Pell, LA Foulder-Hughes, M Lagerstrom, M Ornstein, MG Eide, MJ Davidoff, P Royston, PJ Anderson, RG Record, Richard Dobbie, S Campbell, S Yang, SK Cole, Tze Kin Lau   +25 more
core   +4 more sources

Iron and late preterm [PDF]

Italian Journal of Pediatrics, 2014
Iron is essential for the Central Nervous System development, i.e. mielinization process and cellular differentiation as well as correct functioning of neurotransmitters [1]. Preterm infants show an increased risk of iron deficiency (ID) since 80% of the iron storage at birth is accumulated during the third trimester of pregnancy.
openaire   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Cord blood lipoprotein profile in term, preterm, and late preterm newborns

Journal of Research in Medical Sciences, 2014
Background: High concentrations of triglyceride-rich lipoproteins, and apolipoprotein B in newborns with low gestational age may increase the risk of cardiovascular diseases in the future.
Sedigheh Ghaemi, Raziyeh Najafi, Roya Kelishadi   +2 more
doaj  

Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial. [PDF]

, 2020
BackgroundNitric oxide (NO) plays an important role in normal postnatal transition. Our aims were to determine whether adding inhaled NO (iNO) decreases supplemental oxygen exposure in preterm infants requiring positive pressure ventilation (PPV) during ...
Anderson, Michael, Dannaway, Douglas, Helmbrecht, Ashley, Lakshminrusimha, Satyan, Manfredo, Amy, McCoy, Michael, Noori, Shahab, Riley, Julee, Sekar, Krishnamurthy, Szyld, Edgardo, Wlodaver, Anne   +10 more
core  

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod

Developmental Dynamics, EarlyView.
Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco, Maha Essaidi, Elijah Barnes, Ashley Williams, Karin Vancíková, Margot C. Labberté, Pieter Brama, Niamh C. Nowlan, Joel D. Boerckel   +8 more
wiley   +1 more source

Lactation and neonatal nutrition: defining and refining the critical questions. [PDF]

, 2012
This paper resulted from a conference entitled "Lactation and Milk: Defining and refining the critical questions" held at the University of Colorado School of Medicine from January 18-20, 2012.
Ardythe L. Morrow, Armond Goldman, Barry D. Shur, Carlito B. Lebrilla, D. Hadsell :m. Rijnkels, Dana Dabelea, Daniel J. Raiten, Daniel N. Frank, Danielle G. Lemay, Darryl Hadsell, Edward Janoff, J. Bruce German, Jacob E. Friedman, James L. Mcmanaman, Josef Neu, Joshua Vanhouten, Katie Hinde, Laurie A. Nommsen-rivers, Margaret C. Neville, Maya Bunik, Michael Hambidge, Monique Rijnkels, Nancy F. Krebs, Nelson D. Horseman, Nicole Forman, Nikhat Contractor, Paul S. Maclean, Paula Meier, Peter Williamson, Russell C. Hovey, S. M. Donovan, Sharon M. Donovan, Steven M. Anderson, T. Crume :d. Dabelea, T. M. Badger, Tessa Crume, Thomas M. Badger, Victoria Seewaldt   +37 more
core   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source