Results 101 to 110 of about 108,801 (294)

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial. [PDF]

, 2020
BackgroundNitric oxide (NO) plays an important role in normal postnatal transition. Our aims were to determine whether adding inhaled NO (iNO) decreases supplemental oxygen exposure in preterm infants requiring positive pressure ventilation (PPV) during ...
Anderson, Michael, Dannaway, Douglas, Helmbrecht, Ashley, Lakshminrusimha, Satyan, Manfredo, Amy, McCoy, Michael, Noori, Shahab, Riley, Julee, Sekar, Krishnamurthy, Szyld, Edgardo, Wlodaver, Anne   +10 more
core  

Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren [PDF]

, 2010
<STRONG>Background</STRONG> Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN).
A Brady, AL Rickards, AT Bhutta, BE Stephens, CM McCarton, D Wolke, Daniel F. MacKay, G Wiener, Gordon C. S. Smith, I Kirkegaard, J Briscoe, J Cuzick, Jill P. Pell, LA Foulder-Hughes, M Lagerstrom, M Ornstein, MG Eide, MJ Davidoff, P Royston, PJ Anderson, RG Record, Richard Dobbie, S Campbell, S Yang, SK Cole, Tze Kin Lau   +25 more
core   +4 more sources

Early‐Life Clinical Factors Shape Cerebellar Structure in Preterm‐Born Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Preterm birth alters typical brain development due to complex exposures related to neonatal illness, pain management, and brain injury. Despite an increased understanding of neonatal brain injury on developmental outcomes, the association of cerebellar maturation with school‐age motor and cognitive function remains incompletely ...
Victoria Rapos, Steven Ufkes, Cecil Chau, Jessie van Dyk, Ting Guo, Ruth E. Grunau, Steven P. Miller   +6 more
wiley   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Preterm birth, an unresolved issue [PDF]

, 2013
Premature birth is the world's leading cause of neonatal mortality with worldwide estimates indicating 11.1% of all live births were preterm in 2010.
Belizan, Jose, Buekens, Pierre, Hofmeyr, Justus, Salaria, Natasha   +3 more
core   +1 more source

Late preterm birth is a risk factor for growth faltering in early childhood: a cohort study

BMC Pediatrics, 2009
Background Rates of preterm birth are increasing worldwide and this increase is mostly due to infants born between 34 and 36 weeks of gestational age, the so-called "late preterm" births.
Victora Cesar G, Barros Aluísio JD, Domingues Marlos R, Matijasevich Alicia, Santos Ina S, Barros Fernando C   +5 more
doaj   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod

Developmental Dynamics, EarlyView.
Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco, Maha Essaidi, Elijah Barnes, Ashley Williams, Karin Vancíková, Margot C. Labberté, Pieter Brama, Niamh C. Nowlan, Joel D. Boerckel   +8 more
wiley   +1 more source