Results 31 to 40 of about 45,604 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mid- to Late-Quaternary evolution of the Wilderness Barrier dunes, South Africa [PDF]

, 2011
Barrier dunes represent potentially long-term, but complex, archives of coastal evolution. The examples occupying the Wilderness embayment, on the southern Cape coast of South Africa, form a regionally unique system of three shore-parallel barriers ...
Dunajko, Adam C.
core  

Towards a radiocarbon chronology of the Late-Glacial: Sample selection strategies [PDF]

, 2001
This paper outlines a dating program designed to test the reproducibility of radiocarbon dates on different materials of Late-Glacial age (plant macrofossils, fossil beetle remains, and the "humic" and "humin" chemical fractions of limnic sediments ...
Walker, M. J. C., Walker, M.J.C., Scott, E.M., Bryant, C., Harkness, D.D., Lowe, J. J., Lowe, J.J., Coope, G. R., Coope, G.R., Scott, E. M., Harkness, D. D.   +10 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Late Quaternary Vegetation Development Following Deglaciation of Northwestern Alexander Archipelago, Alaska

Frontiers in Earth Science, 2019
The Cordilleran Ice Sheet covered most of southeastern Alaska during the Last Glacial Interval (LGI: Marine Isotope Stage 2). Ice began to recede from western Alexander Archipelago ∼17,000 ± 700 yr BP.
Thomas A. Ager
doaj   +1 more source

Tephrochronology and its application: A review

, 2011
Tephrochronology (from tephra, Gk ‘ashes’) is a unique stratigraphic method for linking, dating, and synchronizing geological, palaeoenvironmental, or archaeological sequences or events.
Lowe, David J., David J. Lowe
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Depositional record of metal(loid)s since late quaternary in the Laizhou Bay, China

Frontiers in Marine Science
The contamination of marine ecosystems with metal(loid)s is an increasing environmental concern, largely driven by anthropogenic activities, and poses a significant risk to the health of ecosystems and human well-being.
Longlong Liu, Longlong Liu, Junfeng Gao, Shengjiang Zhang, Sen Lin, Dongdong Lu, Jialin Zhang, Xiang Xie, Bin Chen, Jiandong Qiu   +9 more
doaj   +1 more source

Late Quaternary environmental changes recorded in the Danish marine molluscan faunas: Appendices 1-6 [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2004
Late Quaternary, marine deposits in Denmark have yielded 247 subfossil species of molluscs. The sites are presented, and comparisons are made between the subfossil mollusc assemblages and the 278 shell-bearing mollusc species presently living in the ...
Petersen, Kaj Strand
doaj  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source