Results 101 to 110 of about 4,355,728 (290)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Fundamentals of stellar evolution and nucleosynthesis

The theory of stellar structure and evolution plays a pivotal role in modern astrophysics. Stellar evolution calculations are used to determine the ages and, to a lesser extent, distances of stars, which are critical to our knowledge of the history and ...
Diego Vescovi
core   +1 more source

Spectroscopic and Photometric Variability of Three Oxygen Rich Post-AGB “Shell” Objects

Galaxies, 2018
Light, color, and radial velocity data (2007–2015) for HD 161796, V887 Her, and HD 331319, three oxygen-rich post-AGB stars, have thus far not provided direct support for the binary hypothesis to explain the shapes of planetary nebulae and severely ...
Griet C. Van de Steene, Bruce J. Hrivnak, Hans Van Winckel, Julius Sperauskas, David Bohlender   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effects of stellar X-ray photoevaporation on planetesimal formation via the streaming instability

Astronomy & Astrophysics
Context. The formation of planetesimals via the streaming instability (SI) is a crucial step in planet formation, yet its triggering conditions and efficiency are highly sensitive to both disk properties and specific evolutionary processes. Aims.
Ying Xuchu, Liu Beibei, Yang Haifeng, Drążkowska Joanna, Stammler Sebastian M., Zhu Zhaohuan, Eriksson Linn E.J., Deng Hongping, Liu Bin, Chen Ping   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Physics of Evolved Stars: A Conference Dedicated to the Memory of Olivier Chesneau ORGANIC SYNTHESIS IN THE LATE STAGES OF STELLAR EVOLUTION

, 2015
. Infrared and mm-wave observations have revealed a rapid and continuous synthesis of gas-phase and solid organic compounds in the late stages of stellar evolution.
T Lanz, E Lagadec, F Millour, S Kwok
core  

Very Late-time JWST and Keck Spectra of the Oxygen-rich Supernova 1995N

The Astrophysical Journal
We present new JWST/MIRI Medium Resolution Spectroscopy and Keck spectra of SN 1995N obtained in 2022–2023, more than 10,000 days after the supernova (SN) explosion. These spectra are among the latest direct detections of a core-collapse SN, both through
Geoffrey C. Clayton, R. Wesson, Ori D. Fox, Melissa Shahbandeh, Alexei V. Filippenko, Bryony Nickson, Michael Engesser, Schuyler D. Van Dyk, WeiKang Zheng, Thomas G. Brink, Yi Yang, Tea Temim, Nathan Smith, Jennifer Andrews, Chris Ashall, Ilse De Looze, James M. Derkacy, Luc Dessart, Michael Dulude, Eli Dwek, Ryan J. Foley, Suvi Gezari, Sebastian Gomez, Shireen Gonzaga, Siva Indukuri, Jacob Jencson, Joel Johansson, Mansi Kasliwal, Zachary G. Lane, Ryan Lau, David Law, Anthony Marston, Dan Milisavljevic, Richard O’Steen, Justin Pierel, Armin Rest, Arkaprabha Sarangi, Matthew Siebert, Michael Skrutskie, Lou Strolger, Tamás Szalai, Samaporn Tinyanont, Qinan Wang, Brian Williams, Lin Xiao, Szanna Zsíros   +45 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source