Results 181 to 190 of about 4,355,728 (290)

Early phase of shock formation in pair plasma colliding with electron-proton plasma. [PDF]

Sci Rep
Dieckmann ME.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Gradual Destruction of Refractory Stardust in Alkali Brines on Asteroid Bennu. [PDF]

Nat Commun
Haenecour P, Barnes JJ, Bloch E, Smith LR, Hill D, Glavin DP, Dworkin JP, Connolly HC, Lauretta DS.   +8 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

CESAM: A Free Code for Stellar Evolution Calculations

, 2010
Delivery of a public stellar evolution ...
Lebreton, Yveline,, Morel, Pierre,
core  

Discovery of a star sensitive to the spin of Sagittarius A. [PDF]

Nature
Abd El Dayem K, Abuter R, Aimar N, Amaro-Seoane P, Berdeu A, Berger JP, Bourdarot G, Brandner W, Burkert A, Calderón D, Correia C, Cuadra J, Davies R, Defrère D, Delit L, Drescher A, Eisenhauer F, Esteras Otal L, Fabricius M, Feuchtgruber H, Flesch S, Förster Schreiber NM, Foschi A, Fournier Q, Garcia P, Garcia Lopez R, Generozov A, Genzel R, Gillessen S, Gonté F, Haubois X, Hönig SF, Houllé M, Joharle S, Kaufer A, Kammerer J, Kervella P, Kolb J, Kreidberg L, Labadie L, Lacour S, Lai O, Laugier R, Le Bouquin JB, Leftley J, Li R, Lopez B, Lutz D, Mang F, Mérand A, Millour F, Montargès M, Morujão N, Nowacki H, Nowak M, Oberti S, Osorno J, Ott T, Paumard T, Paladini C, Pappert S, Perets HB, Perraut K, Perrin G, Petrov R, Petrucci PO, Piran T, Pourré N, Rabien S, Ribeiro DC, Robbe-Dubois S, Sadun Bordoni M, Sanchez-Bermudez J, Santos D, Sari R, Sauter J, Scheithauer S, Scigliuto J, Shangguan J, Shimizu TT, Soulez F, Stadler J, Straubmeier C, Sturm E, Subroweit M, Sykes C, Tacconi LJ, Thévenet P, Urso I, Vincent F, Woillez J, Zins G, GRAVITY+ Collaboration.   +92 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The orbital dynamics of the LMC and SMC about the Milky Way. [PDF]

Astron Astrophys Rev
Besla G, Kallivayalil N.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A tidal disruption event from an intermediate-mass black hole revealed by comprehensive multi-wavelength observations. [PDF]

Nat Commun
Wang J, Huang M, Xue Y, Jiang N, Huang S, Wang Y, Zhu J, Zhu S, Dai L, Jin C, Luo B, Shu X, Sun M, Wang T, Zou F.   +14 more
europepmc   +1 more source