Results 241 to 250 of about 4,355,728 (290)

Lithium Synthesis in Late Stages of Stellar Evolution

, 2000
openaire   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The chemistry of habitable oceans in the Solar system. [PDF]

Nat Commun
Hao J, Zhu Y, Knoll AH, Tosca NJ, He C, Vetter MCYL, Liao L, Crockford PW, Stüeken EE, Huo A, Li J, Mondal JA, Catling DC, Song Y, Ju P, Pan L, Huang F, Glein CR.   +17 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Short-Course Preoperative Radiation Therapy for Rectal Cancer: Toward a Curative Radio-Immuno-Biological Approach? [PDF]

Adv Radiat Oncol
Koukourakis IM, Verigos EK, Verigos KE, Koukourakis MI.   +3 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

A Faint Progenitor System for the Faint Supernova 2024vjm

Zimmerman E, Gal-Yam A, Groot P, Ofek E, Roestel Jv, Pastorello A, Valenti S, Ravi A, Chen P, Schulze S, Blagorodnova N, Wavasseur M, Gómez-Muñoz M, Tranin H, de Wet S, Leloudas G, Vreeswijk P, Kwok L, Schwab M, Jha S, Maguire K, Sand D, Stringer E, Kupfer T, Faran T, Anderson J, Andrews J, Andrews M, Badash A, Bloemen S, Bostroem K, Chen T, Valle MD, Dimitriadis G, Dong Y, Farah J, Gillanders J, Godson B, Gromadzki M, Hiramatsu D, Hoang E, Howell D, Janzen D, Kuncarayakti H, Li J, Lyman J, Maeda K, Magee M, Mehta D, Milligan A, Moran S, Ni YQ, O’Neill D, Pearson J, Pieterse D, Pignata G, Reguitti A, Reichart D, Retamal NM, Santos R, Scaringi S, Shrestha M, Srivastav S, Stoppa F, Subrayan B, Valerin G, Wang X, Wynn K, Yaron O, Zang W.   +69 more
europepmc   +1 more source

One-third of Sun-like stars are born with misaligned planet-forming disks. [PDF]

Nature
Biddle LI, Bowler BP, Morgan M, Tran QH, Wu YL.   +4 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source